Prediction of thrombophilia in patients with unexplained recurrent pregnancy loss using a statistical model

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Tongfei WangAimin Zhao

Abstract

To establish a statistical model to predict thrombophilia in patients with unexplained recurrent pregnancy loss (URPL). A retrospective case-control study was conducted at Ren Ji Hospital, Shanghai, China, from March 2014 to October 2016. The levels of D-dimer (DD), fibrinogen degradation products (FDP), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (Fg), and platelet aggregation in response to arachidonic acid (AA) and adenosine diphosphate (ADP) were collected. Receiver operating characteristic curve analysis was used to analyze data from 158 UPRL patients (≥3 previous first trimester pregnancy losses with unexplained etiology) and 131 non-RPL patients (no history of recurrent pregnancy loss). A logistic regression model (LRM) was built and the model was externally validated in another group of patients. The LRM included AA, DD, FDP, TT, APTT, and PT. The overall accuracy of the LRM was 80.9%, with sensitivity and specificity of 78.5% and 78.3%, respectively. The diagnostic threshold of the possibility of the LRM was 0.6492, with a sensitivity of 78.5% and a specificity of 78.3%. Subsequently, the LRM was validated with an overall accuracy of 83.6%. The LRM is a valuable m...Continue Reading

References

Feb 24, 2001·American Journal of Reproductive Immunology : AJRI·A RazielR Ron-El
Apr 29, 2003·British Journal of Haematology·Ian J MackieUNKNOWN Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
Oct 26, 2012·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Feb 16, 2015·Obstetrics and Gynecology Clinics of North America·Lora Shahine, Ruth Lathi
Aug 1, 2015·Blood Cells, Molecules & Diseases·Rucha PatilShrimati Shetty
Aug 25, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Xuefeng LuAimin Zhao

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Citations

Apr 13, 2019·The Journal of Obstetrics and Gynaecology Research·Wen YangXiaomin Kang
Apr 16, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tongfei WangFangsun Liu
Jul 1, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ping FangMeijuan Li

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