Prediction of transarterial chemoembolization refractoriness in patients with hepatocellular carcinoma using imaging features of gadoxetic acid-enhanced magnetic resonance imaging

Acta Radiologica
Jieun ByunSeung Soo Lee

Abstract

Repeated transarterial chemoembolization (TACE) can be associated with loss of its efficacy and subsequent tumor progression. To identify features of gadoxetic acid-enhanced magnetic resonance imaging (MRI) associated with TACE refractoriness and to develop a prediction model for estimating the risk of TACE refractoriness. Among 1025 patients with intermediate-stage hepatocellular carcinoma (HCC) who underwent TACE as a first-line treatment during 2010-2017, 427 patients who underwent preoperative gadoxetic acid-enhanced MRI were analyzed. According to the date of initial TACE, patients were divided into the development cohort (n = 211) and the test cohort (n = 216). TACE refractoriness was determined according to the Japan Society of Hepatology guidelines. Univariable and multivariable analyses were performed to investigate the association between clinical/MRI features and TACE refractoriness. The performance of the prediction model was internally and externally assessed using the C-index of discrimination and a Hosmer-Lemeshow goodness-of-fit test for calibration. By analyzing 427 patients, we constructed a prediction model with the following independent features associated with TACE refractoriness: maximum tumor size; tumor ...Continue Reading

References

Jan 5, 2002·The American Journal of Surgical Pathology·Gregory Y LauwersUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
May 4, 2004·Statistics in Medicine·Lisa M SullivanRalph B D'Agostino
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Xiong-Zhi WuDan Chen
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Nov 22, 2011·Journal of Gastroenterology and Hepatology·Hwi Young KimChang-Min Kim
Jan 22, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Joong-Won ParkAnn-Lii Cheng
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Taro YamashitaShuichi Kaneko
Jun 20, 2014·World Journal of Gastroenterology : WJG·Woo Sun RouHeon Young Lee
Apr 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroJulie K Heimbach

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Citations

Aug 28, 2021·Journal of Clinical and Translational Hepatology·Bin-Yan ZhongCai-Fang Ni

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