Prediction of transcriptional activity based on gene association with the nuclear matrix

Biochemical and Biophysical Research Communications
R Buttyan, C A Olsson

Abstract

In this report, we show that androgen-dependent genes expressed in rat ventral prostate, C1, C2 and C3, are enriched in residual DNA extracted from the nuclear matrix of ventral prostate. The enrichment is androgen-dependent and is likely to be related to their transcriptional activity. While this finding corroborates other data demonstrating that transcriptionally active genes can be protected from nuclease digestion by their association with the nuclear matrix, we have extended this analysis to show that nuclear matrix protection experiments can be used both to analyze tissue-specific expression among members of a highly related gene family and also to predict transcriptional activity of genes in particular tissues.

References

Aug 22, 1977·Biochemical and Biophysical Research Communications·B PeetersJ Mous
Jan 5, 1985·Journal of Molecular Biology·B Neuer, D Werner
Oct 23, 1974·Biochemical and Biophysical Research Communications·R Berezney, D S Coffey
Aug 6, 1981·Nature·D A JacksonP R Cook
Sep 11, 1982·Nucleic Acids Research·M ParkerM Page
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P C HentzenI Bekhor
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D A Goldberg
Aug 1, 1982·Molecular and Cellular Endocrinology·M J Page, M G Parker
Mar 1, 1981·Experimental Cell Research·R Berezney, L A Buchholtz

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Citations

Dec 1, 1991·Journal of Cellular Biochemistry·R H GetzenbergD S Coffey
Sep 1, 1992·Cancer Metastasis Reviews·M P TenniswoodJ E Welsh
Aug 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·A T Adylova, Ia Kh Turakulov
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S I DworetzkyG S Stein
Mar 21, 1998·The Journal of Urology·B R KonetyR H Getzenberg
Mar 1, 1994·Molecular and Cellular Biology·K NakagomiT Kohwi-Shigematsu
Apr 1, 1989·Experimental Cell Research·C M ReadT Moss

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