PMID: 793564Dec 1, 1976Paper

Prediction of tricyclic antidepressant response: a critical review

Archives of General Psychiatry
R J Bielski, R O Friedel


This article reviews all the prospective, double-blind controlled studies that have evaluated the prediction of response to imipramine hydrochloride and amitriptyline hydrochloride in depressed patients. Despite widely divergent methodologies, an attempt is made to extract clinically useful conclusions from these data. Critiques of each study and the criteria used in their evaluation are presented, with suggestions for future research included. The predictors of positive response to imipramine and amitriptyline are as follows: upper socioeconomic class, insidious onset, anorexia, weight loss, middle and late insomnia, and psychomotor disturbance. The predictors of poor response are the following: neurotic, hypochondriacal, and hysterical traits, multiple prior episodes, and delusions. Pretreatment urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels may some day be useful in predicting to which of these two tricyclic antidepressants a patient will respond.


Jan 1, 1993·European Archives of Psychiatry and Clinical Neuroscience·H J MöllerD von Zerssen
Jul 14, 1999·Journal of Affective Disorders·M E Thase, E S Friedman
Dec 13, 1995·Journal of Affective Disorders·R A BurnsM T Abou-Saleh
Dec 24, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Nicola J WilesGlyn Lewis
Nov 1, 1989·Journal of General Internal Medicine·H G KoenigD G Blazer
Jun 24, 2008·Neuropsychiatric Disease and Treatment·Madhukar H TrivediA John Rush
Dec 1, 1987·The Australian and New Zealand Journal of Psychiatry·Philip B Mitchell
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·H E Klein, N Müller
Mar 18, 2003·Journal of Clinical Psychopharmacology·Jeffrey L RauschMaria E Johnson
May 1, 1979·Psychological Medicine·V A Rao, A Coppen
Nov 1, 1978·Psychological Medicine·R M Murray, D L Murphy
Aug 24, 1990·Pharmaceutisch Weekblad. Scientific Edition·A J Loonen, G J Zwanikken
Jul 1, 1986·Psychiatry Research·C J FairchildM Khatami
Apr 23, 2003·Biological Psychiatry·Andrea Fagiolini, D J Kupfer
Apr 23, 2003·Biological Psychiatry·K Ranga Rama Krishnan
May 1, 1994·Journal of Affective Disorders·J J Brophy
Sep 1, 1986·Journal of Affective Disorders·S C GoldbergR O Friedel
Dec 1, 1984·Journal of Affective Disorders·J A HamiltonS Pinkel
Aug 1, 1983·Journal of Affective Disorders·M E ThaseD J Kupfer
Sep 1, 1980·Journal of Affective Disorders·J W StewartD F Klein
Jan 1, 1982·Behaviour Research and Therapy·P H Wilson
Nov 1, 1979·Psychosomatics·J J SilvermanR O Friedel
Jan 1, 1981·Journal of the American Academy of Child Psychiatry·A D Kramer, R J Feiguine
Mar 24, 2009·Depression and Anxiety·David W MorrisA J Rush
Feb 7, 2007·Acta Psychiatrica Scandinavica. Supplementum·Walter A Brown
Jan 5, 2013·Depression and Anxiety·Felipe A JainAndrew F Leuchter
Jun 1, 1987·Biological Psychiatry·A GeorgotasJ Welkowitz
Jun 1, 1984·Journal of Behavior Therapy and Experimental Psychiatry·M E ThaseD P Greenwald
Apr 1, 1979·General Hospital Psychiatry·J R Neill
Sep 1, 1985·Journal of Affective Disorders·M M Robertson, M R Trimble
May 1, 1980·Comprehensive Psychiatry·D J KupferD H Shaw
May 1, 1979·Comprehensive Psychiatry·H Pétursson
Jun 1, 1980·General Hospital Psychiatry·Q R Regestein, P Reich
May 1, 1993·Comprehensive Psychiatry·H Kuhs
Sep 1, 1982·Journal of the American Geriatrics Society·R C Veith
Nov 1, 1979·Comprehensive Psychiatry·R K Blashfield, L C Morey
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·G VogelD Kors
Jun 5, 2003·The Psychiatric Clinics of North America·Andrew A Nierenberg
Jun 3, 2009·The American Journal of Orthopsychiatry·Lydia Falconnier
May 2, 2008·The International Journal of Neuropsychopharmacology·Colleen K LooJanet L Taylor
Jan 1, 1980·International Journal of Psychiatry in Medicine·B V Reifler, N G Ward
Jan 1, 1988·International Journal of Psychiatry in Medicine·J SchwartzE Clavier
Nov 14, 2012·Psychotherapy and Psychosomatics·Giovanni A Fava
Dec 12, 2012·Journal of Psychopharmacology·Colin HendrieEmma Robinson
Jun 1, 1991·Acta Neuropsychiatrica·J J HoofA J van den Berg
Nov 1, 1996·Comprehensive Psychiatry·R W Lam, J N Stewart
Jan 1, 1990·Comprehensive Psychiatry·I W MillerG I Keitner
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·A L BouhuysR H Van den Hoofdakker
Sep 1, 1979·Disease-a-month : DM·A M Cooper, C A Shamoian
Jan 1, 1992·General Hospital Psychiatry·R J GregoryR H Paulsen
Dec 1, 1979·The Australian and New Zealand Journal of Psychiatry·L G KilohM D Neilson
Feb 11, 2004·The Journal of Nervous and Mental Disease·Michael A PosternakMark Zimmerman
Oct 11, 2017·The International Journal of Neuropsychopharmacology·Sho MoriguchiTetsuya Suhara
Sep 8, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Mark ZimmermanKasey Stanton
May 1, 1980·Acta Psychiatrica Scandinavica·J DavidsonR D Miller
Oct 1, 1982·Acta Psychiatrica Scandinavica·A E Skodol, R L Spitzer
Jun 1, 1997·Acta Psychiatrica Scandinavica·Y LecrubierD Hackett
Jun 9, 2004·Neurotoxicity Research·D F Klein, Jonathan Stewart
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillBoris B Gorzalka
Feb 2, 1999·The British Journal of Psychiatry : the Journal of Mental Science·F M QuitkinD F Klein
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·C F DugganR M Murray
Dec 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·A S Lee, R M Murray
May 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·P MatussekD Nagel
Feb 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·H U FischM O'Reilly
Jun 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·E S PaykelE R Rassaby
Dec 6, 2000·Journal of Clinical Psychopharmacology·D S Robinson, K Rickels
Jan 1, 1997·European Psychiatry : the Journal of the Association of European Psychiatrists·S Priebe, M Bröker
Mar 1, 1986·Journal of the American Geriatrics Society·S Borson, M Raskind
Sep 17, 2003·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Marcelo Pio de Almeida FleckAssociação Médica Brasileira
Mar 1, 1988·Journal of General Internal Medicine·C KaplanG H Gordon
May 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·P R RowanR R Parker
Jan 1, 1986·Suicide & Life-threatening Behavior·B L Tanney
Nov 6, 1998·Statistical Methods in Medical Research·T Johnson
Jul 1, 2009·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Marcelo P FleckLuis Alberto Hetem
Jun 1, 1989·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S H Kennedy, R T Joffe
Jan 1, 1979·Journal of the American Psychoanalytic Association·G Heilbrunn
Feb 1, 1986·Australian Paediatric Journal·P Birleson

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