Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study.

BMC Medicine
Matias C VieiraUPBEAT Consortium

Abstract

All obese pregnant women are considered at equal high risk with respect to complications in pregnancy and birth, and are commonly managed through resource-intensive care pathways. However, the identification of maternal characteristics associated with normal pregnancy outcomes could assist in the management of these pregnancies. The present study aims to identify the factors associated with uncomplicated pregnancy and birth in obese women, and to assess their predictive performance. Data form obese women (BMI ≥ 30 kg/m2) with singleton pregnancies included in the UPBEAT trial were used in this analysis. Multivariable logistic regression was used to identify sociodemographic, clinical and biochemical factors at 15+0 to 18+6 weeks' gestation associated with uncomplicated pregnancy and birth, defined as delivery of a term live-born infant without antenatal or labour complications. Predictive performance was assessed using area under the receiver operating characteristic curve (AUROC). Internal validation and calibration were also performed. Women were divided into fifths of risk and pregnancy outcomes were compared between groups. Sensitivity, specificity, and positive and negative predictive values were calculated using the upper...Continue Reading

References

Mar 9, 2006·American Journal of Obstetrics and Gynecology·William A Grobman, David M Stamilio
Feb 25, 2009·BMJ : British Medical Journal·Karel G M MoonsDouglas G Altman
Mar 2, 2010·Diabetes Care·UNKNOWN International Association of Diabetes and Pregnancy Study Groups Consensus PanelMaria Ines Schmidt
Jul 15, 2015·The Lancet. Diabetes & Endocrinology·Lucilla PostonUNKNOWN UPBEAT Trial Consortium
Oct 10, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A E IvanescuD B Allison
Nov 26, 2015·Obstetrics and Gynecology
Oct 17, 2016·The Lancet. Diabetes & Endocrinology·Lucilla PostonMatthew W Gillman
Dec 23, 2016·Obesity·Matias C VieiraUNKNOWN SCOPE Consortium

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Citations

Oct 16, 2018·BioMed Research International·Radzisław MierzyńskiBożena Leszczyńska-Gorzelak
Dec 31, 2020·Journal of Midwifery & Women's Health·Cecilia M JevittDiana R Jolles
Feb 13, 2021·International Journal of Molecular Sciences·Carmen PheifferSumaiya Adam

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Software Mentioned

Stata
UPBEAT

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