Prediction of whole-genome risk for selection and management of hyperketonemia in Holstein dairy cattle

Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie
K A WeigelHeather M White

Abstract

Hyperketonemia (HYK), a common early postpartum health disorder characterized by elevated blood concentrations of β-hydroxybutyrate (BHB), affects millions of dairy cows worldwide and leads to significant economic losses and animal welfare concerns. In this study, blood concentrations of BHB were assessed for 1,453 Holstein cows using electronic handheld meters at four time points between 5 and 18 days postpartum. Incidence rates of subclinical (1.2 ≤ maximum BHB ≤ 2.9 mmol/L) and clinical ketosis (maximum BHB ≥ 3.0 mmol/L) were 24.0 and 2.4%, respectively. Variance components, estimated breeding values, and predicted HYK phenotypes were computed on the original, square-root, and binary scales. Heritability estimates for HYK ranged from 0.058 to 0.072 in pedigree-based analyses, as compared to estimates that ranged from 0.071 to 0.093 when pedigrees were augmented with 60,671 single nucleotide polymorphism genotypes of 959 cows and 801 male ancestors. On average, predicted HYK phenotypes from the genome-enhanced analysis ranged from 0.55 mmol/L for first-parity cows in the best contemporary group to 1.40 mmol/L for fourth-parity cows in the worst contemporary group. Genome-enhanced predictions of HYK phenotypes were more closel...Continue Reading

References

May 22, 1998·Journal of Dairy Science·Y T GröhnJ A Hertl
Oct 7, 2000·The Veterinary Clinics of North America. Food Animal Practice·T Duffield
Apr 6, 2001·Genetics·T H MeuwissenM E Goddard
Dec 14, 2004·Journal of Dairy Science·S J LeBlancT F Duffield
Mar 21, 2007·Journal of Dairy Science·A P W de RoosG de Jong
Jan 24, 2009·Journal of Dairy Science·T F DuffieldK E Leslie
May 19, 2009·Journal of Dairy Science·M IwersenW Heuwieser
Aug 25, 2012·Journal of Dairy Science·J A A McArtG R Oetzel
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·M P L CalusR F Veerkamp
Mar 13, 2014·Journal of Dairy Science·K L Parker GaddisC Maltecca
Nov 13, 2014·Animal : an International Journal of Animal Bioscience·C Egger-DannerK F Stock
Jan 19, 2016·Journal of Dairy Science·J P ChesnaisF Miglior
Jun 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Adriana García-RuizCurtis P Van Tassell
Mar 28, 2017·Journal of Dairy Science·N VukasinovicS K DeNise

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Citations

Mar 12, 2019·Animal : an International Journal of Animal Bioscience·A BenedetM De Marchi
Oct 8, 2019·Journal of Dairy Science·T D W LukeJ E Pryce
Mar 3, 2020·Journal of Dairy Science·Michael C FerrisSteven R Wangen
Dec 7, 2019·Animals : an Open Access Journal From MDPI·Francisco A Leal YepesHeather J Huson
May 6, 2021·Animals : an Open Access Journal From MDPI·Ryan S PralleHeather M White
Jun 29, 2021·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Laura FalchiNicolò P P Macciotta

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