Predictions of children's emotionality from evolutionary and epigenetic hypotheses

Scientific Reports
Jonathan HillHelen Sharp

Abstract

Sex-dependent effects of mismatched prenatal-postnatal maternal conditions are predicted by combining two evolutionary hypotheses: that foetal conditions provide a forecast of likely postnatal environments (Predictive Adaptive Response), and that the female foetus is better adapted than the male to maternal adversity (Trivers-Willard hypothesis). Animal studies have implicated glucocorticoid mechanisms modifiable by effects of postnatal tactile stimulation on glucocorticoid receptor gene expression. In this study we examined behavioural predictions in humans based on these evolutionary and epigenetic models. Mothers in a general population cohort provided self-reported anxiety scores at 20 weeks pregnancy, and at 9 weeks, 14 months and 3.5 years postpartum, and frequency of infant stroking at 9 weeks. Mothers and teachers reported child symptoms at 7 years. SEM models with maximum-likelihood estimates made use of data from 887 participants. There was a three-way interaction between prenatal and postnatal anxiety and maternal stroking in the prediction of irritability, seen only in girls. This arose because lower maternal stroking was associated with higher irritability, only in the mismatched, low-high and high-low maternal anx...Continue Reading

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Citations

Mar 21, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Elizabeth C BraithwaiteJonathan Hill
May 7, 2020·Depression Research and Treatment·Monika Talarowska
Mar 23, 2021·Journal of Developmental Origins of Health and Disease·Calan Savoy, Ryan J Van Lieshout

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