Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data

Scientific Reports
J White BearJames H McKerrow

Abstract

Infection by the human blood fluke, Schistosoma mansoni involves a variety of cross-species protein- protein interactions. The pathogen expresses a diverse arsenal of proteins that facilitate the breach of physical and biochemical barriers present in skin evasion of the immune system, and digestion of human plasma proteins including albumin and hemoglobin, allowing schistosomes to reside in the host for years. However, only a small number of specific interactions between S. mansoni and human proteins have been identified. We present and apply a protocol that generates testable predictions of S. mansoni-human protein interactions. In this study, we have preliminary predictions of novel interactions between schistosome and human proteins relevant to infection and the ability of the parasite to evade the immune system. We applied a computational whole-genome comparative approach to predict potential S. mansoni-human protein interactions based on similarity to known protein complexes. We first predict S. mansoni -human protein interactions based on similarity to known protein complexes. Putative interactions were then scored and assessed using several contextual filters, including the use of annotation automatically derived from li...Continue Reading

References

Jul 1, 1991·Experimental Parasitology·M W Bennett, J P Caulfield
Jan 15, 1991·Biochemical and Biophysical Research Communications·O WiedowB Utecht
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J PearceA Sher
Oct 1, 1986·Experimental Parasitology·A Ruppel, D J McLaren
Dec 7, 1972·Biochimica Et Biophysica Acta·M H Dresden, H L Asch
Mar 1, 1995·Memórias do Instituto Oswaldo Cruz·Z Fishelson
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·M TendlerA S Simpson
Jul 14, 1999·The American Journal of Tropical Medicine and Hygiene·M IsmailJ L Bennett
Dec 11, 1999·Nucleic Acids Research·J QuackenbushJ Upton
May 10, 2000·Journal of Molecular Biology·I BotosE F Meyer
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·M A Martí-RenomA Sali
Sep 20, 2000·The Journal of Biological Chemistry·J P SalterJ H McKerrow
Aug 24, 2001·Journal of Molecular Biology·E Sprinzak, H Margalit
Apr 19, 2002·The New England Journal of Medicine·Allen G P RossDonald P McManus
Oct 9, 2002·Nature·Malcolm J GardnerBart Barrell
Jun 26, 2003·Nucleic Acids Research·Narayanan EswarAndrej Sali
Oct 24, 2003·Infection and Immunity·Jiusheng DengZvi Fishelson
Dec 19, 2003·Nucleic Acids Research·Evelyn CamonRolf Apweiler
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Sep 14, 2004·Immunological Reviews·Thomas A WynnMargaret M Mentink-Kane
Feb 19, 2005·Cellular and Molecular Life Sciences : CMLS·E Bornberg-BauerJ Weiner
Jun 29, 2005·Nucleic Acids Research·Iaroslav IspolatovSergei Maslov
Aug 23, 2005·Molecular & Cellular Proteomics : MCP·Giselle M KnudsenJames H McKerrow
Nov 23, 2005·The Journal of Experimental Medicine·Philip SmithPadraic G Fallon
Apr 26, 2006·Parasitology Research·Gabriela Ribeiro-dos-SantosLuciana C C Leite
Jun 2, 2006·Nucleic Acids Research·Fred P DavisM S Madhusudhan
Dec 7, 2006·Nucleic Acids Research·T J P HubbardE Birney
Feb 20, 2007·Memórias do Instituto Oswaldo Cruz·Diana BahiaGuilherme Oliveira
Apr 25, 2007·Molecular and Biochemical Parasitology·Melaine DelcroixJames H McKerrow
Jul 17, 2007·Molecular Immunology·Akhmed AslamRichard J Pleass
Oct 30, 2007·Protein Science : a Publication of the Protein Society·Fred P DavisAndrej Sali
Jan 31, 2008·Genome Research·Malay Kumar BasuEugene V Koonin
Jul 17, 2008·PLoS Neglected Tropical Diseases·Elizabeth HansellJames H McKerrow
Oct 16, 2008·BMC Evolutionary Biology·January WeinerErich Bornberg-Bauer
Mar 19, 2009·Parasite Immunology·M L BurkeD P McManus
Jul 17, 2009·Nature·Matthew BerrimanNajib M El-Sayed
Aug 28, 2009·The Journal of Biological Chemistry·Weizhi LiuRichard E Davis

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Citations

May 5, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Sara SorgiEduardo L V Silveira
May 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Aya Al-NaseriNoha Mahana

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Methods Mentioned

BETA
interaction predictions
Electrophoresis
elastase assay
interaction prediction
confocal microscopy

Software Mentioned

ModPipe
MODTIE
MODELLER
MODTIDE
MODBASE
PIBASE
ENSEMBL

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