PMID: 6975158Nov 1, 1981Paper

Predictive ability of Lukes-Collins classification for immunologic phenotypes of childhood non-Hodgkin lymphoma: an institutional series and literature review

Cancer
W M CristA Flint

Abstract

Tissues from 22 children with non-Hodgkin lymphoma (NHL) were studied pathologically and immunologically. Most children were noted to have marked (B- or T-cell) neoplasms and the Lukes-Collins classification was predictive of immunologic phenotype in cases where markers were present. Our series and a review of the literature demonstrates that most abdominal NHL are B-cell in origin and are often small noncleaved follicular center cell lymphoma (Burkitt type). Most mediastinal primary lesions are T-cell in origin and of convoluted cell morphology. A few neoplasms (often peripheral nodal) lack the characteristic surface immunoglobulin or erythrocyte rosetting properties of B- or T-cell lesions, respectively. Frequently marrow and central nervous system involvement are observed in T-cell lymphomas and are not in frequent in B cell neoplasms. Shared immunologic and clinical features between the B- or T-cell lymphomas and their leukemic counterparts support the concept that they often differ only in the stage of disease progression.

References

Aug 1, 1979·The Journal of Clinical Investigation·E L ReinherzS F Schlossman
Aug 1, 1976·Cancer·B N NathwaniH Rappaport
Jul 1, 1966·The Journal of Pathology and Bacteriology·L A Hemsley
Oct 1, 1974·Cancer·R J Lukes, R D Collins
Apr 1, 1973·Clinical Immunology and Immunopathology·J WybranH H Fudenberg

❮ Previous
Next ❯

Citations

Apr 1, 1983·Pediatric Annals·R V Gardner, J Graham-Pole
May 9, 1996·The New England Journal of Medicine·J T SandlundW M Crist
May 1, 1983·Acta Pathologica Japonica·K AozasaA Okada
Sep 1, 1988·Acta Pathologica Japonica·T MizugamiK Asanuma
May 1, 1983·Journal of Clinical Pathology·P IsaacsonD Y Mason
Jul 1, 1992·Critical Reviews in Oncology/hematology·L WhiteT C Quah
Apr 1, 1984·The Journal of Dermatologic Surgery and Oncology·G R Krüger
Jan 1, 1985·The Journal of Pathology·S Variend
Jan 15, 2013·The Journal of Molecular Diagnostics : JMD·Iris SchrijverScott D Boyd
Jun 15, 1987·Cancer·M A BitterJ W Vardiman
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·H Takahashi, M L Hansmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.