Predictive ability of sequential surveys in determining donor loss from increasingly stringent variant Creutzfeldt-Jakob disease deferral policies

Transfusion
Sheila F O'brienEleftherios C Vamvakas

Abstract

Predonation screening questions about travel increase the safety of the blood supply from diseases such as variant Creutzfeldt-Jakob disease (vCJD) and malaria. This study examines the ability of sequential surveys to predict actual travel deferrals and the operational validity of travel questions. To assess donor travel histories before implementing key deferral policies, two donor surveys were carried out at Canadian Blood Services collection sites in February 1999 (8026 donors) and March 2001 (13,623 donors). In-person interviews were carried out with 1530 donors to assess the operational validity of the short travel question. Time-series analysis was used to determine whether there was a change in deferrals when deferral policies were implemented. Predicted donor loss estimates based on survey results were compared with actual deferrals. Deferrals increased significantly (p < 0.05) when vCJD deferral policies were implemented in October 1999 and September 2001, but not in October 2000. Survey data accurately predicted deferrals 6 months after implementation from the initial policy (2.51% predicted vs. 2.51% actual), but there were fewer deferrals than predicted for the second (2.89% predicted vs. 2.26% actual, p < 0.01) and...Continue Reading

References

Mar 26, 1997·JAMA : the Journal of the American Medical Association·A E WilliamsG J Nemo
Dec 16, 1998·Psychological Bulletin·M S Shum
Jul 29, 2000·Transfusion Medicine Reviews·J ChiavettaT L Chambers
Sep 19, 2002·American Journal of Therapeutics·Marc Germain, Mindy Goldman
Jul 19, 2003·Transfusion·S E Rugege-HakizaUNKNOWN Retrovirus Epidemiology Donor Study
Apr 24, 2004·Transfusion·Edward L MurphyPascale Reich
Aug 11, 2004·Lancet·Alexander H PedenJames W Ironside

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Citations

Aug 5, 2008·Transfusion·David A LeibyEdward P Notari
Jul 14, 2006·Transfusion·Sheila F O'Brien
Dec 21, 2006·Transfusion·Mindy GoldmanSheila F O'Brien

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