Predictive accuracy of serum total calcium for both critically high and critically low ionized calcium in critical illness

Journal of Clinical Laboratory Analysis
Zhi-De HuYan-Qiu Han

Abstract

The accuracy of total calcium and its corrected value for predicting critically high and critically low ionized calcium in critical illness is controversial. The aim of this study was to investigate whether the concentration of total serum calcium, either corrected for albumin or not, could predict critically high or low values in critical illness. This report describes a retrospective study using the Medical Information Mart for Intensive Care (MIMIC) III database. Test panels that contained serum albumin, total calcium, and ionized calcium (named ATI panels) with order time intervals of less than one hour were extracted. The predictive accuracy of total calcium, either corrected for albumin or not, was assessed using receiver operating characteristic (ROC) curve analysis. A total of 12 118 ATIs with 103 critically low and 92 critically high ionized calcium results were extracted. The areas under ROC curves (AUCs) of corrected and uncorrected total calcium for predicting critically low ionized calcium were 0.69 (95% CI: 0.61-0.76) and 0.70 (95% CI: 0.63-0.78), respectively. For predicting critically high ionized calcium, the AUCs were 0.98 (95% CI: 0.97-1.00) and 0.97 (95% CI: 0.95-1.00), respectively. With positive predictive...Continue Reading

References

Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Feb 24, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·R W BurnettUNKNOWN International Federation of Clinical Chemistry and Laboratory Medicine. IFCC Scientific Division, Working Group on Selective
Jan 27, 2009·Clinical Chemistry·Geoffrey S BairdWayne Chandler
Mar 25, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Elisa Piva, Mario Plebani
Nov 26, 2010·Critical Care Medicine·Moritoki EgiRinaldo Bellomo
Jan 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Geoffrey S Baird
May 10, 2012·Clinical Biochemistry·David B Endres
Jun 6, 2013·Critical Care : the Official Journal of the Critical Care Forum·Tom SteeleIngeborg Welters
Oct 21, 2014·Critical Reviews in Clinical Laboratory Sciences·Qing H Meng, Elizabeth A Wagar
Apr 6, 2016·Annals of Translational Medicine·Zhongheng Zhang
May 25, 2016·Scientific Data·Alistair E W JohnsonRoger G Mark

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