PMID: 9187692Jun 1, 1997Paper

Predictive accuracy of transrectal ultrasound-guided prostate biopsy: correlations to matched prostatectomy specimens

Urology
M DanzigerJ A Fracchia

Abstract

To characterize observed differences in Gleason score between prostate biopsy and corresponding radical retropubic prostatectomy (RRP) specimens. One hundred consecutive clinically localized prostate cancers diagnosed by transrectal ultrasound-guided biopsy (TRUS-Bx) and treated with RRP were reviewed. All specimens were evaluated in blinded review by a single expert uropathologist and contrasted with the initial histologic analysis, performed by multiple pathologists. Mean Gleason score of TRUS-Bx specimens for blinded review and at initial evaluation were 6.6 +/- 0.1 and 6.0 +/- 0.1 (P < 0.001). Corresponding RRP values were 6.8 +/- 0.1 and 6.5 +/- 0.1 (P < 0.03). Differences in Gleason score between TRUS-Bx and RRP at initial evaluation were significant (P < 0.02), but not in blinded review (P = NS). In blinded review, TRUS-Bx correctly predicted RRP histology for 88% of men with lesions scored as Gleason 5 to 7 and 41% of men with well-(Gleason score of 2 to 4) or poorly differentiated (Gleason score of 8 to 10) lesions (P < 0.01). TRUS-Bx does not accurately reflect RRP histology when predicting well- or poorly differentiated lesions. Prostate cancer treatment algorithms should not be predicated upon biopsy histology alone...Continue Reading

References

Mar 1, 1985·Urology·P C SoganiW F Whitmore
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Aug 1, 1994·The American Journal of Surgical Pathology·D G Bostwick
Jan 27, 1994·The New England Journal of Medicine·G W ChodakJ Warner

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Citations

Nov 13, 2004·The Journal of Urology·P EmiliozziV Pansadoro
Oct 10, 2001·The Urologic Clinics of North America·M R Feneley, A W Partin
Jun 17, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·José CuryMiguel Srougi

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