Predictive and prognostic value of de novo MET expression in patients with advanced non-small-cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Anna LiYi-Long Wu

Abstract

Cellular-mesenchymal-epithelial transition (MET) protein has recently been identified as a novel target that shows promise for the treatment of non-small-cell lung cancer (NSCLC). However, the relationship between de novo MET expression and patient outcomes remains unclear. We reviewed the data of patients who had been diagnosed with NSCLC between December 2013 and October 2014. All the patients were evaluated for MET expression status. MET-positive was defined as having an H-score ≥ 60 by immunohistochemistry analysis. MET expression was analyzed in 158 patients who were negative for the common driver genes, including EGFR, ALK, KRAS and ROS1. A chi-squared test was used to assess the clinicopathological parameters. Multivariate analyses were performed using the Cox proportional hazards model. MET data were available for analysis in 158 advanced NSCLC patients. Of these, based on the MET H-score criteria, the IHC-positive rate was 48.1% (76/158). There were more patients with adenocarcinoma in the MET-positive group compared with the MET-negative group (P=0.01). Nine patients with lymphoepithelioma-like carcinoma had no MET expression. There was no significant difference in overall survival (OS) between MET-positive and -negat...Continue Reading

References

Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Issan Yee San TamMaria P Wong
Dec 30, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Yves DouillardEdward S Kim
Feb 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·D Ross CamidgeRobert C Doebele
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sai-Hong Ignatius OuA John Iafrate
Jun 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tatsuya YoshimasuYoshitaka Okamura
Aug 30, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Keisei TachibanaMasayuki Noguchi
Sep 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiangdong LiuPeggy A Scherle
Dec 27, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Koji TsutaHitoshi Tsuda
Jan 13, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rafal DziadziuszkoFred R Hirsch
Apr 24, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jin Hyun ParkDae Seog Heo
Aug 14, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A T ShawG V Scagliotti
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tianhong LiDavid R Gandara
Apr 2, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hartmut KoeppenRobert L Yauch
Apr 12, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ling HuangYi-Long Wu
May 9, 2014·Nature Biotechnology·Cormac Sheridan
May 23, 2014·JAMA : the Journal of the American Medical Association·Mark G KrisPaul A Bunn
Aug 3, 2014·The Annals of Thoracic Surgery·Yung-Han SunKuan-Jeng Chen
Dec 24, 2014·Expert Opinion on Therapeutic Targets·Anna LiYi-Long Wu
Mar 31, 2015·Expert Review of Anticancer Therapy·Christian RolfoFederico Cappuzzo
Apr 4, 2015·World Journal of Gastroenterology : WJG·Yan LiuZi-Hua Luo
Apr 12, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yih-Leong ChangPan-Chyr Yang

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Citations

Aug 25, 2016·Toxicology Letters·Mohamed E ShakerMohamed El-Mesery
Apr 25, 2020·Japanese Journal of Clinical Oncology·Kohei ShitaraToshihiko Doi
Jul 4, 2020·Expert Opinion on Emerging Drugs·Toshio FujinoTetsuya Mitsudomi
Sep 6, 2020·Cancer·Alex FriedlaenderAlfredo Addeo
Dec 27, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Theresa A BoyleUNKNOWN Lung Cancer Mutation Consortium (LCMC) Pathologist Panel Group

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