Predictive factors and impact of no reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction

Circulation. Cardiovascular Interventions
Gjin NdrepepaAdnan Kastrati

Abstract

The investigation of no-reflow phenomenon after percutaneous coronary intervention (PCI) in patients with acute ST-segment-elevation myocardial infarction has therapeutic implications. We investigated the predictive factors, persistence in time, and impact of no reflow on myocardial salvage, ventricular function, and mortality. The study included 1140 patients with ST-segment-elevation myocardial infarction undergoing primary PCI and paired scintigraphic examinations (before intervention and 7 to 14 days thereafter). After primary PCI, 108 patients had no reflow and 1032 patients had normal coronary flow. The median salvage index was 0.34 (interquartile range, 0.15, 0.49) in patients with no reflow versus 0.55 (interquartile range, 0.29, 0.81) in patients with normal flow (P<0.001). Left ventricular ejection fraction at 6 months after PCI was 47.7+/-13.1% in the no-reflow group versus 54.2+/-13.9% in the group with normal flow after PCI (P<0.001). In 80.3% of patients with no reflow, normalization of blood flow >6 months after PCI occurred and correlated with improvement in the left ventricular ejection fraction. Independent predictors of no reflow were residual flow in the infarct-related artery (P<0.001), initial perfusion de...Continue Reading

References

Dec 1, 1974·The Journal of Clinical Investigation·R A KlonerR B Jennings
Oct 1, 1967·The American Journal of Cardiology·T Killip, J T Kimball
Dec 22, 1999·The Journal of Experimental Medicine·M GriselliM B Pepys
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Thorsten ReffelmannRobert A Kloner
Oct 19, 2004·Journal of the American College of Cardiology·Raymond J GibbonsAllan S Jaffe
Aug 18, 2006·Basic Research in Cardiology·Thorsten Reffelmann, Robert A Kloner
Aug 26, 2006·Nature Clinical Practice. Cardiovascular Medicine·Hiroshi Ito
Jul 10, 2007·Journal of the American College of Cardiology·Gjin NdrepepaAdnan Kastrati
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Nov 21, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Shereif H Rezkalla, Robert A Kloner

❮ Previous
Next ❯

Citations

Jun 29, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stefanie SchulzJulinda Mehilli
May 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Eva S KehmeierTienush Rassaf
Dec 18, 2013·European Heart Journal. Acute Cardiovascular Care·Amber M OttenUNKNOWN Zwolle Myocardial Infarction study Group
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
May 10, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gjin NdrepepaAdnan Kastrati
Mar 23, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Adriano CaixetaUNKNOWN Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial investigators
Apr 4, 2015·International Journal of Cardiology·Alessandro Durante, Paolo G Camici
Dec 20, 2011·The American Journal of Cardiology·William ChanUNKNOWN Melbourne Interventional Group Investigators
Mar 30, 2016·The American Journal of Cardiology·Sungmin LimKi-Bae Seung
Dec 1, 2015·Archives of Cardiovascular Diseases·Claire BouletiStéphane Germain
Sep 25, 2014·Journal of Interventional Cardiology·Cindy L GrinesTheodore Schreiber
Sep 16, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nicola S VosMaarten A Vink
Nov 15, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hyuma DaidojiIsao Kubota
Sep 18, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Yaniv LeviShahar Lavi
Jun 10, 2017·Journal of the American College of Cardiology·Jacob LønborgUNKNOWN DANAMI-3 Investigators
Dec 8, 2016·Coronary Artery Disease·John F Beltrame
Oct 24, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Burak AyçaM Hakan Dinckal
Mar 30, 2018·Cardiovascular Intervention and Therapeutics·Yukio OzakiUNKNOWN Task Force on Primary Percutaneous Coronary Intervention (PCI) of the Japanese Cardiovascular Interventional Therapeutics (C
Mar 28, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Xiao-Ming GaoXiao-Jun Du
Jun 26, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gjin NdrepepaAdnan Kastrati
Jul 6, 2018·Current Atherosclerosis Reports·Ahmadreza Karimianpour, Anbukarasi Maran
May 16, 2018·Heart·Sri Raveen Kandan, Thomas William Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.