Predictive Factors Determining the Overall Outcome of Primary Spinal Glioblastoma Multiforme: An Integrative Survival Analysis

World Neurosurgery
Subhas K KonarAnil Nanda

Abstract

Primary glioblastoma multiforme of the spinal cord is a rare entity. The aim of this study was to perform an integrative analysis of patients whose cases were selected from the published studies, and to examine the influence of various factors on overall outcomes. A PubMed search was performed for literature published from 1938 to 2015 to select the articles containing information about the demographics, tumor location, critical event (death), time to events, and treatment characteristics. One hundred twenty-eight cases of spinal glioblastoma were selected for analysis. Patients between 18 and 65 years of age had a better overall survival rate (14 months) compared with those of "extreme" age outside that range (<18 years, 10.5 months, and >65 years, 2 months; log-rank P = 0.0005). Univariate analysis showed age between 18 and 65 years (hazard ratio [HR] = 0.121; 95% confidence interval [CI] = 0.04-0.37; P = 0.0005) and surgery with radiotherapy (HR = 3.71; 95% CI = 1.36-10.13; P = 0.01) had a significant correlation with overall survival. In multivariate analysis, thoracic spine (odds ratio [OR] = 0.154; 95% CI = 0.033-0.717; P = 0.017) and conus (OR = 0.091; 95% CI = 0.010-0.798; P =0.030) tumor had a lesser chance for mortali...Continue Reading

References

Sep 1, 1992·Journal of Neurosurgery·F J EpsteinD Freed
Apr 11, 1992·Neurosurgery·H M SandlerD A Ross
Jan 1, 1989·Journal of Neurosurgery·A R CohenF Epstein
Apr 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·M HelyG Selby
Jan 1, 1981·Acta neurochirurgica·W GrisoldK Jellinger
Mar 1, 1981·Journal of Neurosurgery·B GuidettiR Vagnozzi
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·H ShiratoH Abe
Dec 1, 1996·Journal of Neurosurgery·S ConstantiniF J Epstein
Jul 1, 1997·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G J PrzybylskiA J Martinez
Apr 15, 1999·Pediatric Neurosurgery·T E MerchantR A Sanford
Jun 10, 2000·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·S NishioM Fukui
Jul 25, 2003·Cancer·Mariarita SantiElisabeth J Rushing
Aug 9, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·George I JalloFred Epstein
Sep 29, 2004·Pediatric Blood & Cancer·Ian F Pollack
Mar 11, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Vivek BondeAtul Goel
Aug 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Kiernan J MinehanMichael P Wright
Mar 24, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jianjun SunBin Liu
Mar 30, 2010·International Journal of Radiation Oncology, Biology, Physics·Rahul D TendulkarThomas E Merchant
Dec 9, 2010·Rare Tumors·Robert LoberJohn Cowell
Mar 26, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Matthew R SanbornWilliam C Welch
Aug 16, 2011·Journal of Neurological Surgery. Part A, Central European Neurosurgery·S A KönigU Spetzger
Dec 27, 2011·The Spine Journal : Official Journal of the North American Spine Society·Kanji MoriYoshitaka Matsusue
Feb 7, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chiagozie OnoniwuGeorge Jallo
Jul 25, 2012·Neurology India·G Lakshmi PrasadAshok K Mahapatra
Jan 16, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Philip J O'HalloranDavid O'Brien
Aug 8, 2014·Surgical Neurology International·Stephanus ViljoenPatricia A Kirby

❮ Previous
Next ❯

Citations

May 11, 2016·Chinese Journal of Cancer·Antonella CacchioneAndrea Carai
Nov 22, 2018·Journal of Neuro-oncology·F M MoinuddinMohamad Bydon
Apr 1, 2017·Journal of Neurosurgery. Pediatrics·Andrew S LuksikGeorge I Jallo
Sep 20, 2019·The Neurohospitalist·Jocelyn RodriguezRobert C Bucelli
Jul 1, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Lei ChengZuowei Wang
Nov 25, 2020·Neuro-Chirurgie·D KitumbaA Marques Baptista
Sep 19, 2020·ACS Chemical Neuroscience·Mahendran BhaskaranThirumalaraju Vaishnavi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.