Predictive Factors for Developing Venous Thrombosis during Cisplatin-Based Chemotherapy in Testicular Cancer

Urologia Internationalis
Isabel HeideggerDavid Pfister

Abstract

Malignancies and cisplatin-based chemotherapy are both known to correlate with a high risk of venous thrombotic events (VTT). In testicular cancer, the information regarding the incidence and reason of VTT in patients undergoing cisplatin-based chemotherapy is still discussed controversially. Moreover, no risk factors for developing a VTT during cisplatin-based chemotherapy have been elucidated so far. We retrospectively analyzed 153 patients with testicular cancer undergoing cisplatin-based chemotherapy at our institution for the development of a VTT during or after chemotherapy. Clinical and pathological parameters for identifying possible risk factors for VTT were analyzed. The Khorana risk score was used to calculate the risk of VTT. Student t test was applied for calculating the statistical significance of differences between the treatment groups. Twenty-six out of 153 patients (17%) developed a VTT during chemotherapy. When we analyzed the risk factors for developing a VTT, we found that Lugano stage ≥IIc was significantly (p = 0.0006) correlated with the risk of developing a VTT during chemotherapy. On calculating the VTT risk using the Khorana risk score model, we found that only 2 out of 26 patients (7.7%) were in the ...Continue Reading

Citations

Dec 14, 2018·World Journal of Urology·Pia PaffenholzAxel Heidenreich
Feb 11, 2020·Japanese Journal of Clinical Oncology·Satoshi NittaHiroyuki Nishiyama
Apr 6, 2019·Frontiers in Neurology·Chiara MandojLaura Conti
Dec 11, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jakob LauritsenGedske Daugaard
Jun 12, 2020·International Journal of Cancer. Journal International Du Cancer·Lene ThorsenHelene F S Negaard
Mar 10, 2021·Nature Reviews. Urology·Michal ChovanecGedske Daugaard
Oct 16, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T MurezA Méjean
Jun 15, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hikmat Abdel-RazeqRayan Bater

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