Nov 20, 2018

Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorder

BJPsych Open
Ichiro KusumiNorihiro Sato


Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression. We also examined whether hyperglycaemic progression varied among patients receiving monotherapy with the six most frequently used antipsychotics. High baseline serum triglycerides and coexisting hypertension significantly predicted hyperglycaemic progression. The six most frequently used antipsychotics did not significantly differ in their associated hyperglycaemic progression rates over the 1-year observation period. Clinicians should carefully evaluate baseline serum triglycerides and coexisting hypertension and perform strict longitudinal monitoring irrespective of the antipsychotic used. The authors report no financial or other relationship that is relevant to the subject of this article. Relevant f...Continue Reading

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Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Glycerol Kinase
Bipolar Disorder
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Drug Industry

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