Predictive factors for positive disco-vertebral biopsy culture in pyogenic vertebral osteomyelitis, and impact of fluoroscopic versus scanographic guidance

BMC Infectious Diseases
Caroline DiffreAurélien Dinh

Abstract

The aims of this study were to identify the predictive factors for microbiological diagnosis through disco-vertebral biopsy (DVB) in patients with pyogenic vertebral osteomyelitis (PVO) and negative blood cultures, and compare the performance of DVB under fluoroscopic versus scanographic guidance. We performed a cohort study comparing positive and negative DVB among patients with PVO. All cases of PVO undergoing a DVB for microbiological diagnosis in our center were retrospectively reviewed. Infections due to Mycobacterium tuberculosis, infections on foreign device, and non-septic diseases were excluded. Anamnestic, clinical, biological, microbiological, as well as radiological data were collected from medical charts thanks to a standardized data set. A total of 111 patients were screened; 88 patients were included. Microbiological cultures were positive in 53/88 (60.2%) patients. A thickening of the paravertebral tissue ≥10 mm on magnetic resonance imaging (MRI) in axial MR scans was a predictive factor of DVB microbiological positivity (52.4% vs. 13.3%; p = 0.006; OR = 5.4). Overall, 51 DVB were performed under fluoroscopic guidance and 37 under scanographic guidance. Considering lumbar DVB, 25/36 (69.4%) of cases yielded pos...Continue Reading

References

Aug 1, 1991·Radiology·D L RenfrewK G Harris
Apr 1, 1990·Surgical Neurology·R K OsenbachA H Menezes
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A J TordaR Bradbury
Oct 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C PerronneM F Kahn
Jan 1, 1996·The American Journal of Medicine·M HonanG M Eisenberg
Oct 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K RieneckE Gutschik
Jun 1, 1997·The Journal of Bone and Joint Surgery. American Volume·E J Carragee
Mar 21, 1998·Archives of Internal Medicine·A G JensenN Frimodt-Møller
Apr 27, 2000·Archives of Pathology & Laboratory Medicine·E LucioP A Adegboyega
Jun 15, 2000·Archives of Orthopaedic and Trauma Surgery·D C WirtzF U Niethard
Jun 28, 2000·Spine·A G HadjipavlouA J Muffoletto
Feb 12, 2002·Seminars in Arthritis and Rheumatism·Joan M NollaFrancesc Gudiol
Mar 21, 2002·Surgical Neurology·Jonathan A FriedmanMichael J Ebersold
May 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin C McHenryGeri A Locker
Oct 7, 2004·Postgraduate Medical Journal·J J RankineR A Dickson
May 9, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Hasan Kamil SucuMustafa Minoğlu
May 23, 2007·AJR. American Journal of Roentgenology·Jim S WuAndrew H Haims
Mar 8, 2008·Journal of Clinical Pathology·D A EnochN M Brown
Jun 14, 2008·Seminars in Arthritis and Rheumatism·E MylonaA Skoutelis
Aug 5, 2008·The Journal of Bone and Joint Surgery. American Volume·Ali NourbakhshKim J Garges
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-L RouxM Rottman
Mar 1, 2011·European Journal of Radiology·Christoph M HeyerStefan P Lemburg
May 26, 2012·AJNR. American Journal of Neuroradiology·B J KimH S Kang
May 31, 2012·Radiologic Clinics of North America·Felix E Diehn
Sep 24, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G GrasL Bernard
Sep 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elie F BerbariDouglas R Osmon
Apr 22, 2016·Scandinavian Journal of Rheumatology·M JeanA Dinh

❮ Previous
Next ❯

Citations

Aug 21, 2020·Skeletal Radiology·Asif SaifuddinSyed Ehtasham Junaid
Jul 17, 2021·EFORT Open Reviews·Ricardo SousaMiguel Araújo Abreu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
sedation
biopsies

Software Mentioned

Statistical Package for Social Science

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.