Predictive factors for prognosis following unsedated percutaneous endoscopic gastrostomy in ALS patients

Muscle & Nerve
Kota BokudaImaharu Nakano

Abstract

This study aimed to determine the prognostic factors and the values that predict survival after percutaneous endoscopic gastrostomy (PEG) tube placement in patients with amyotrophic lateral sclerosis (ALS). We retrospectively analyzed the correlations for 97 consecutive patients with ALS between clinical parameters and survival following PEG tube placement using the log-rank test and Cox proportional-hazards models. The log-rank test showed that an arterial carbon dioxide pressure (PaCO2 ) of ≤ 40 mmHg (P = 0.0054), a forced vital capacity (FVC) of ≥ 38% of predicted (P = 0.0003), and bulbar-onset (P = 0.0121) were significantly associated with better post-PEG survival. Multivariate analysis showed that the FVC and PaCO2 were associated with better post-PEG survival (P = 0.0081 and P = 0.0265, respectively). PEG tube placement in ALS is recommended when FVC is ≥ 38% of predicted and when PaCO2 is normal. Muscle Nerve 54: 277-283, 2016.

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Citations

Aug 15, 2018·Muscle & Nerve·Chiharu MatsudaMichiko Haraguchi
Apr 3, 2020·Rinshō shinkeigaku = Clinical neurology·Kota BokudaToshio Shimizu
Jul 30, 2020·Minerva gastroenterologica e dietologica·Peter ElbeMiroslav Vujasinovic
Sep 12, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Eun Young KimWon Ah Choi
Jul 5, 2018·Frontiers in Neurology·Xueping ChenHuifang Shang

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