Predictive Factors for the Long-Term Deterioration of Pulmonary Function in Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies

Respiration; International Review of Thoracic Diseases
Hideaki YamakawaTakashi Ogura

Abstract

Little has been reported on long-term pulmonary function trends among patients with interstitial lung disease associated with anti-aminoacyl-tRNA synthetase antibodies (ARS-ILD). To clarify the factors predictive of progression in ARS-ILD based on patients' initial clinical and radiological features. The clinical courses of 88 patients with > 1 year of follow-up data on pulmonary function tests (PFTs) were retrospectively analyzed. Disease behavior was categorized into three groups: (1) improved or (2) worsened (defined as increases or decreases, respectively, of > 10% in forced vital capacity and > 15% in %diffusing capacity of lung carbon monoxide) or (3) stable based on PFT changes compared between 1-year results as the initial data and results at 3 years to assess the long-term course. In the initial course of 75 patients with ARS-ILD who received anti-inflammatory therapy within 6 months after diagnosis, 48 patients (64.0%) improved and 6 patients (8.0%) worsened. The radiological patterns in the patients with ARS-ILD included nonspecific interstitial pneumonia (NSIP) in 46.7% and NSIP with organizing pneumonia overlap in 52.0% of the cases. One-third of the initially improved patients who worsened over the long-term cours...Continue Reading

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Citations

Jun 17, 2019·The Journal of Rheumatology·Montserrat Ixchel González-PérezJorge Rojas-Serrano
Sep 11, 2019·Current Opinion in Rheumatology·Michela GasparottoAndrea Doria
Aug 20, 2019·Clinical Rheumatology·Aryeh Fischer, Jörg Distler
Sep 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Panagiotis PanagopoulosAthanasios Tzioufas
Nov 13, 2021·Critical Reviews in Clinical Laboratory Sciences·Konstantinos I TsamisIoannis Sarmas

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