Predictive Factors for the Metachronous Development of High-risk Lesions in the Remnant Pancreas After Partial Pancreatectomy for Intraductal Papillary Mucinous Neoplasm

Annals of Surgery
Yoshihiro MiyasakaMasao Tanaka

Abstract

To identify factors predicting the development of high-risk lesions in the remnant pancreas after surgery for intraductal papillary mucinous neoplasm (IPMN). IPMN has unique features, including multifocality, adenoma-carcinoma sequence, and the development of distinct pancreatic ductal adenocarcinoma (PDAC) in the same pancreas. Careful attention should, therefore, be paid to the metachronous occurrence of high-risk lesions, including high-grade dysplasia or invasive carcinoma (HGD/INV) of IPMN and concomitant PDAC in the remnant pancreas after partial pancreatectomy for IPMN. Clinicopathologic and surveillance data for 195 patients who underwent partial pancreatectomy for IPMN were reviewed retrospectively. Thirteen patients exhibited metachronous development of high-risk lesions including 6 HGD/INV and 7 concomitant PDACs in the remnant pancreas. The 5- and 10-year cumulative incidences of metachronous high-risk lesions in the remnant pancreas were 7.8% and 11.8%, respectively. Twelve of 13 patients had high-risk lesions at the time of initial surgery, and 10 of the 13 IPMNs were located in the distal pancreas. The IPMN subtypes initially resected were gastric in 6 patients, intestinal in 5, and pancreatobililary in the remai...Continue Reading

References

May 29, 2004·Annals of Surgery·Taylor A SohnKeith D Lillemoe
Aug 10, 2005·Virchows Archiv : an International Journal of Pathology·Toru FurukawaSuguru Yonezawa
Dec 6, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaUNKNOWN International Association of Pancreatology
Jul 23, 2008·Archives of Surgery·Thomas SchnelldorferMichael B Farnell
Oct 18, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jacob R MillerC Max Schmidt
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masao TanakaUNKNOWN International Association of Pancreatology
Feb 12, 2013·Journal of the American College of Surgeons·Jin HeChristopher L Wolfgang
Jun 21, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Timothy L FrankelPeter J Allen

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Citations

Apr 28, 2017·Scandinavian Journal of Gastroenterology·Linus AronssonDaniel Ansari
May 19, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Linda M PakPeter J Allen
Aug 27, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·G O CeyhanH Friess
Dec 1, 2017·Archives of Pathology & Laboratory Medicine·Meredith E PittmanRalph H Hruban
Jan 15, 2019·Pancreas·Masao Tanaka
Dec 7, 2019·Surgery Today·Seiko Hirono, Hiroki Yamaue
Aug 16, 2016·Pancreas·Mark Steven MillerJo Ann S Rinaudo
Jun 5, 2018·Annals of Gastroenterological Surgery·Masafumi NakamuraTakao Ohtsuka
Feb 6, 2019·Gastroenterology·Aatur D SinghiAnirban Maitra
Aug 11, 2021·Insights Into Imaging·Giovanni MoranaSilvia Venturini

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