Predictive factors of daily opioid use and quality of life in adults with sickle cell disease

Hematology
Matthew S KarafinJoshua J Field

Abstract

In adults with sickle cell disease (SCD), pain often necessitates opioid use. Few studies have examined the relationship between opioid use and health-related quality of life (HRQOL) in adults with SCD. We tested the hypothesis that higher doses of opioids are associated with worse HRQOL. A cross-sectional cohort study was performed in adults with SCD who completed standardized and validated HRQOL questionnaires: Patient Health Questionnaire-15 (PHQ-15), Patient Health Questionnaire-9 (PHQ-9), Medical Outcome Study 36 Item Short Form (SF-36), and Generalized Anxiety Disorder questionnaire (GAD-7). Daily outpatient opioid dose was converted into morphine milligram equivalents (MME) and categorized as < 90 mg/day or ≥ 90 mg/day. Subject's questionnaire scores were compared by opioid dose. Ninety-nine adults completed questionnaires. The majority had HbSS and median age was 30 years. The median MME was 80 mg/day. When the association between HRQOL and opioid dose was compared, those prescribed ≥ 90 MME had significantly lower SF-36 subscale scores in 7 of 8 domains, and significantly higher severity scores in the PHQ-15, GAD-7, and the PHQ-9 in comparison those prescribed < 90 MME. Using a multivariable regression tree analysis, i...Continue Reading

References

Jan 1, 1992·Progress in Neurobiology·R D TreedeJ N Campbell
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
May 3, 2000·American Journal of Epidemiology·A Ashley-KochR S Olney
Jun 29, 2001·Anesthesia and Analgesia·X LiJ D Clark
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Nov 14, 2003·The New England Journal of Medicine·Jane C Ballantyne, Jianren Mao
Apr 17, 2004·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jordi AlonsoUNKNOWN IQOLA Project Group
Mar 26, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mieke RijkenFrançois G Schellevis
Apr 26, 2005·American Journal of Hematology·Samir K Ballas, Margaret Lusardi
May 24, 2006·Archives of Internal Medicine·Robert L SpitzerBernd Löwe
Sep 21, 2007·The American Journal on Addictions·James L LevensonWally R Smith
Dec 26, 2007·Psychosomatic Medicine·James L LevensonWally R Smith
Jan 16, 2008·Annals of Internal Medicine·Wally R SmithSusan D Roseff
Oct 22, 2009·Psychology, Health & Medicine·Monika R AsnaniMarvin E Reid
Jul 27, 2010·Pediatric Blood & Cancer·Carlton DampierUNKNOWN Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium (CTC)
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
Jan 26, 2011·American Journal of Hematology·Carlton DampierUNKNOWN Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium (CTC) Site Investigators
Apr 7, 2011·JAMA : the Journal of the American Medical Association·Amy S B BohnertFrederic C Blow
Oct 30, 2013·Pediatric Blood & Cancer·Amanda M BrandowJulie A Panepinto
Mar 5, 2014·JAMA Internal Medicine·Jane A Gwira BaumblattTimothy F Jones
Jan 13, 2015·Pain Practice : the Official Journal of World Institute of Pain·Miriam O EzenwaDiana J Wilkie
May 16, 2015·Pediatric Blood & Cancer·Amanda M BrandowJulie A Panepinto
May 20, 2015·Journal of Opioid Management·Wally R SmithSusan D Roseff
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Deborah DowellRoger Chou
Jun 21, 2016·American Journal of Preventive Medicine·C Patrick CarrollClaudia M Campbell
Jan 10, 2017·The Journal of Pain : Official Journal of the American Pain Society·Carlton DampierWilliam Zempsky
Dec 1, 2017·Blood·Huy TranKalpna Gupta
Jan 4, 2018·Blood Advances·Soheir S AdamLaura M De Castro

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