Predictive Factors of Early Recurrence in Patients with Distal Cholangiocarcinoma after Pancreaticoduodenectomy

Gastroenterology Research and Practice
Yasuhiro ItoYuko Kitagawa

Abstract

To determine the factors associated with early recurrence in patients with distal cholangiocarcinoma after pancreaticoduodenectomy (PD). Sixty-one patients with distal cholangiocarcinoma were enrolled. The clinical data and histopathological findings were collected retrospectively. Patients were divided into two groups as follows: 16 patients (26%) with early recurrence and 45 patients (74%) with late recurrence or no recurrence. In a univariate analysis, lymph node metastases (P = 0.0016), lymphatic invasion (P < 0.0001), pancreatic invasion (P = 0.0006), and perineural invasion (P = 0.0004) were significantly different between the two groups. In a multivariate analysis, a higher incidence of lymphatic invasion was the only independent risk factor for early recurrence (odds ratio: 5.772, 95% confidence interval: 1.123-29.682, P = 0.036). Moreover, the disease-free survival and overall survival of patients with a higher incidence of lymphatic invasion were significantly worse compared with those of patients with a lower incidence of lymphatic invasion (P < 0.001). Our study showed that a higher incidence of lymphatic invasion was a significant predictor of early recurrence in patients with distal cholangiocarcinoma. Therefore, ...Continue Reading

References

Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N WolmarkN J Petrelli
Apr 14, 1999·The British Journal of Surgery·S TakaoT Aikou
Oct 5, 2002·Cancer·Tadahiro TakadaUNKNOWN Study Group of Surgical Adjuvant Therapy for Carcinomas of the Pancreas and Biliary Tract
Jul 1, 2005·The New England Journal of Medicine·Chris TwelvesWerner Scheithauer
Aug 6, 2005·Journal of Gastroenterology·Takehiro NojiToshiaki Morikawa
Dec 21, 2006·Annals of Surgical Oncology·Qingbao ChengMengchao Wu
Feb 6, 2007·Journal of Surgical Oncology·Yoshiaki MurakamiTaijiro Sueda
Apr 26, 2007·Annals of Surgery·Michelle L DeOliveiraRichard D Schulick
Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
Jul 6, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sarah B FisherShishir K Maithel
Nov 23, 2013·Journal of the Korean Surgical Society·Young Jae ChungDong Hun Kim
Jun 11, 2014·World Journal of Gastroenterology : WJG·Hyung Jun KwonYoon Jin Hwang
Jan 23, 2015·The British Journal of Surgery·M KiriyamaUNKNOWN Nagoya Surgical Oncology Group

❮ Previous
Next ❯

Citations

Sep 25, 2019·Surgery Today·Masayuki AkitaTakumi Fukumoto
Feb 8, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ken Min ChinMikel Prieto

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.