PMID: 15847256Apr 26, 2005

Predictive factors of low HCO3- levels in peritoneal dialysis patients

Clinical Nephrology
E KasimatisD G Oreopoulos


Metabolic acidosis is a major metabolic abnormality in end-stage renal disease (ESRD) and alkali is provided with dialysis treatment to patients on chronic peritoneal dialysis (CPD) to keep their acid-base balance within normal serum HCO3- levels. We examined the levels of venous serum HCO3- in 163 patients on CPD and the predictive factors for HCO3- levels low enough to indicate metabolic acidosis. The mean value for HCO3- was 26+/-2.4 mmol/l and for anion gap was 13.1+/-3.1 mEq/l. A serum bicarbonate concentration of less than 24 mmol/l, compatible with metabolic acidosis, was observed in 13.5% of the patients. In a multivariate analysis HCO3- levels were directly correlated with older age and use of CaCO3- as phosphate binders, and inversely associated with serum potassium, the use of sevelamer and low lactate dialysis solutions. Higher serum urea levels, the use of low lactate solutions and sevelamer instead of CaCO3 were significantly predictive factors for HCO3- levels < 24 mmol/l. Venous HCO3- and anion gap values were within the normal ranges in stable CPD patients. In 13.5% of them, however, chronic metabolic acidosis was observed based on venous HCO3- levels < 24 mmol/l. Dietary protein intake, the use of sevelamer an...Continue Reading


Feb 27, 2013·Advances in Chronic Kidney Disease·Karthik K Tennankore, Joanne M Bargman
Jul 15, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P ChauveauChristian Combe
Oct 13, 2009·Renal Failure·Jan KlabochOtto Schück

Related Concepts

Metabolic Acidosis
Carbonic Acid Ions
Kidney Failure, Chronic
Peritoneal Dialysis
Retrospective Studies
Dialysis Solutions
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