Predictive Factors of Positive Circumferential and Longitudinal Margins in Early T3 Colorectal Cancer Resection

International Journal of Surgical Oncology
M Ashraf BalbaaEmad M Abdelrahman

Abstract

Malignant involvement of circumferential resection margin (CRM) and longitudinal resection margin (LRM) after surgical resection of colorectal cancer (CRC) are associated with higher rates of recurrence and development of distant metastasis. This can influence the overall patient's prognosis. The aim of the current study was to identify pathological factors as predictors for the involvement of resection margins in early T3 CRC. Patients and Methods. Fifty patients radiologically diagnosed to have cT3a/b (CRC) were included in the study. After resection, the pathological examination was performed to identify patients with positive CRM and/or LRM. Relations between the different pathological parameters and the CMR and LRM involvements were assessed. Positive CRM was present in 17 cases (34%), while positive LRM was found in 6 cases (12%). The involvement of both margins was significantly associated with rectal tumors and tumors with infiltrative gross appearance, grade III, deeper invasion, and positive lymph node metastases. Also, there was a significant association between both margins' positivity and other pathological parameters as signet ring carcinoma, tumor budding, perineural and vascular invasion, high microvessel densit...Continue Reading

References

Jan 1, 1985·Advances in Cancer Research·J Folkman
Feb 1, 1994·Pathology, Research and Practice·P Hermanek, C Wittekind
Aug 20, 2002·Arquivos De Gastroenterologia·Cláudio TartaVinícius Duval da Silva
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iris D Nagtegaal, Phil Quirke
Nov 20, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W HohenbergerS Merkel
Oct 2, 2009·Archives of Pathology & Laboratory Medicine·Mary Kay WashingtonUNKNOWN Members of the Cancer Committee, College of American Pathologists
Dec 20, 2011·Critical Reviews in Oncology/hematology·Shawn P CareyCynthia A Reinhart-King
Nov 5, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cornelis J H van de VeldeVincenzo Valentini
Jul 16, 2014·Biochemical and Biophysical Research Communications·Yasuhisa Fukui
Feb 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian-Hong FangShi-Mei Zhuang
Apr 30, 2015·Acta Oncologica·Anders JakobsenJesper Vilandt
Jul 2, 2015·JAMA Surgery·Ramzi AmriDavid L Berger
Oct 17, 2015·Annals of Surgery·Aaron S RicklesUNKNOWN Consortium for Optimizing the Treatment of Rectal Cancer (OSTRiCh)
Nov 26, 2015·Case Reports in Oncology·Peter Y ParkMadappa N Kundranda
Dec 10, 2016·SpringerPlus·Ricardo RochaVítor Nunes
Dec 13, 2016·American Journal of Surgery·Arielle KantersSamantha Hendren
Jan 21, 2017·International Journal of Molecular Sciences·Inés MármolMaría Jesús Rodriguez Yoldi
Nov 16, 2017·Cancer Management and Research·Xiangquan KongJinluan Li
Feb 9, 2018·Medical Archives·Samir Delibegovic
Mar 10, 2018·Diseases of the Colon and Rectum·Satish K WarrierAlexander G Heriot
Apr 11, 2018·Scientific Reports·Ryan K OroscoQuyen T Nguyen
May 10, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Committee
Dec 5, 2018·BJS Open·E LuziettiC Kontovounisios
Feb 24, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Martin C S WongZhi-Jie Zheng
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Committee

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Citations

Aug 25, 2021·Abdominal Radiology·Meena SutharAvanish Saklani

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Methods Mentioned

BETA
biopsy
biopsies
dissection
light microscopy
surgical resection

Software Mentioned

SPSS

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