Predictive factors of relapse in low-risk gestational trophoblastic neoplasia patients successfully treated with methotrexate alone

American Journal of Obstetrics and Gynecology
Florence CouderF Golfier

Abstract

Patients with 2000 FIGO low-risk gestational trophoblastic neoplasia are commonly treated with single-agent chemotherapy. Methotrexate is widely used in this indication in Europe. Analysis of relapse after treatment and identification of factors associated with relapse would help understand their potential impacts on 2000 FIGO score evolution and chemotherapy management of gestational trophoblastic neoplasia patients. This retrospective study analyzes the predictive factors of relapse in low-risk gestational trophoblastic neoplasia patients whose hormone chorionic gonadotropin (hCG) normalized with methotrexate alone. Between 1999 and 2014, 993 patients with gestational trophoblastic neoplasia were identified in the French Trophoblastic Disease Reference Center database, of which 465 were low-risk patients whose hCG normalized with methotrexate alone. Using univariate and multivariate analysis we identified significant predictive factors for relapse after methotrexate. The Kaplan-Meier method was used to plot the outcome of patients. The 5-year recurrence rate of low-risk gestational trophoblastic neoplasia patients whose hCG normalized with methotrexate alone was 5.7% (confidence interval [IC], 3.86-8.46). Univariate analysis ...Continue Reading

Citations

Nov 7, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Nadeem R Abu-RustumJillian Scavone
May 20, 2020·International Journal of Molecular Sciences·Przemysław KoźmińskiEwa Gniazdowska
Apr 30, 2019·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Danielle B ChauRebecca Stone
Jul 28, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benoit YouFrancois Golfier

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