Predictive factors of resolution of primary vesico-ureteric reflux: a multivariate analysis

BJU International
Jose Maria Penido SilvaEduardo Araujo Oliveira

Abstract

To identify independent factors predicting the resolution of primary vesico-ureteric reflux (VUR) in a cohort of medically managed children. Between 1977 and 2003, 506 children were diagnosed with VUR and were conservatively managed and prospectively followed. All of the children were maintained on antibiotic prophylaxis. Follow-up imaging consisted of voiding cysto-urethrography (VCUG) or a direct isotope cystogram at intervals of 2-3 years. The predictive factors used are based on the patient data at the time of entry in the protocol. The dependent variable was VUR resolution. The criterion for resolution was based on a single negative VCUG or direct isotope cystogram. A survival analysis identified variables significantly associated with VUR resolution. Cox's regression model was applied to identify variables independently associated with the dependent variable. After adjustment, four variables remained as independent predictors of VUR resolution: nonwhite race, relative risk (95% confidence interval) of 1.5 (1.1-1.9; P = 0.009); mild grade of VUR, 3.3 (2.1-5.3; P < 0.001); absence of renal damage, 3.3 (2.4-4.5; P < 0.001); and absence of dysfunctional voiding, 2.0 (1.4-3.1; P < 0.001). For mild VUR, three variables were sig...Continue Reading

References

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Citations

Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jose Maria Penido SilvaEduardo Araujo Oliveira
Jan 8, 2011·Current Urology Reports·Joel F Koenig, Patrick H McKenna
Jul 8, 2008·Advances in Urology·Sarel Halachmi, Walid A Farhat
Jul 21, 2009·Seminars in Nephrology·Lorraine E Bell, Tej K Mattoo
Jun 24, 2010·The Urologic Clinics of North America·Nathaniel K Ballek, Patrick H McKenna
Dec 22, 2009·The Journal of Urology·Glenn M CannonHiep T Nguyen
Dec 19, 2016·Journal of Pediatric Urology·J NordenströmS Sjöström
Apr 4, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Shina KawaiHideo Nakai
Mar 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·José Murillo BastosUbirajara Barroso
Dec 13, 2019·Indian Journal of Pediatrics·Ranjeet Wishram Thergaonkar, Pankaj Hari
Jun 15, 2017·Investigative and Clinical Urology·Ted Lee, John M Park
Jun 2, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joanna C Clothier, Anne J Wright
Jan 1, 2019·Current Treatment Options in Pediatrics·Emily StonebrookJohn David Spencer
Jul 13, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Shina KawaiToshinori Aihara
Jun 15, 2007·Current Opinion in Urology
Aug 24, 2011·Pediatrics·Jonathon L MaguirePatricia C Parkin

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