Abstract
Predictive factors of the virologic success of the use of lopinavir/ritonavir (LPV/r) in HIV-infected children are unknown, especially in children who have been pretreated with protease inhibitors (PIs). This longitudinal, single-center, observational study included 69 children (21 PI-naive and 48 PI-experienced) who had received LPV/r for at least 3 months. The mean (+/- SD) age was 10.3 +/- 4.8 years, and the mean baseline of CD4 percentage and HIV-1 RNA was 14.9% +/- 9.8% and 4.8 +/- 1.05 log10 copies/mL, respectively. The mean duration of follow-up was 16.5 +/- 8.3 months. At 6, 12, and 18 months, 52%, 57%, and 49% of all children, respectively, had a viral load less than 50 copies/mL. The risk of virologic failure, defined as 2 consecutive viral loads greater than 1000 copies/mL, was significantly higher when the children were previously treated with PIs and when the baseline LPV mutation score exceeded 3 mutations. In the pretreated children, the ratio of the plasma LPV maximal concentration to the baseline LPV score mutation was also associated with failure, independently of resistance score. Finally, in children failing an LPV-containing regimen, accumulation of additional PI-associated resistance mutations was evidence...Continue Reading
References
Jul 6, 2000·Journal of Clinical Microbiology·M MourouxV Calvez
Jul 20, 2001·Journal of Virology·D J KempfR A Rode
Mar 21, 2002·The Lancet Infectious Diseases·Annemarie M C van RossumRonald de Groot
Jun 28, 2002·The New England Journal of Medicine·Sharon WalmsleyUNKNOWN M98-863 Study Team
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Bernard MasquelierUNKNOWN Groupe d' Epidémiologie Clinique du SIDA en Aquitaine
Nov 30, 2002·International Journal of Antimicrobial Agents·Pablo BarreiroVincent Soriano
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Anne-Geneviève MarcelinUNKNOWN Genophar Study Group
Mar 14, 2003·The Pediatric Infectious Disease Journal·Xavier Sáez-LlorensEugene Sun
Mar 29, 2003·Drugs·Risto S Cvetkovic, Karen L Goa
May 27, 2003·Therapeutic Drug Monitoring·Kim KeilGene Morse
Jul 19, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laura MonnoGioacchino Angarano
Aug 23, 2003·The Journal of Infectious Diseases·Dechao Wang, Brendan Larder
Citations
Aug 11, 2005·Current HIV/AIDS Reports·Michael Neely, Andrea Kovacs
May 21, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J M Treluyer
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tommy F Liu, Robert W Shafer
Feb 25, 2011·AIDS Research and Human Retroviruses·Barbara S TaylorLouise Kuhn
Sep 5, 2009·The Journal of Antimicrobial Chemotherapy·Thanyawee PuthanakitKiat Ruxrungtham
May 2, 2009·Current Opinion in Infectious Diseases·Ravindra K GuptaDeenan Pillay
Jul 16, 2008·Antimicrobial Agents and Chemotherapy·Brian L RobbinsUNKNOWN PACTG 1038 Team
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Vincent JullienJean-Marc Tréluyer
Jun 15, 2007·BMC Infectious Diseases·Beatriz LarruJosé T Ramos
Jan 9, 2013·Antiviral Therapy·Torsak BunupuradahUNKNOWN TApHOD
Jul 16, 2010·Analytical and Bioanalytical Chemistry·Roland J W MeestersRob A Gruters
Sep 30, 2009·HIV Medicine·Jt Ramos
Oct 26, 2012·HIV Medicine·N WattanutchariyaP Oberdorfer
Mar 30, 2017·PloS One·Patricia Rojas SánchezUNKNOWN Madrid Cohort of HIV-1 Infected Children and Adolescents Integrated in the Paediatric Branch of the Spanish National AIDS Ne
Mar 24, 2011·The Pediatric Infectious Disease Journal·Pierre FrangeMarie-Laure Chaix
Jul 4, 2007·Journal of Medical Virology·Constance DelaugerreStéphane Blanche
Oct 13, 2005·The Pediatric Infectious Disease Journal·Jintanat AnanworanichUNKNOWN HIV-NAT 017 Study Team
Sep 21, 2005·Journal of Medical Virology·Constance DelaugerreVincent Calvez
Dec 24, 2005·The Pediatric Infectious Disease Journal·Marie-Laure ChaixPhilippe Msellati
Feb 24, 2006·HIV Medicine·M I WatebaF Raffi
Feb 1, 2006·The Journal of Antimicrobial Chemotherapy·Salvador ResinoUNKNOWN Spanish Group of HIV Infection
Oct 1, 2005·The Journal of Antimicrobial Chemotherapy·José Luis JiménezUNKNOWN Spanish Group of Paediatric HIV Infection
Jun 4, 2008·The Pediatric Infectious Disease Journal·Pope KosalaraksaUNKNOWN HIV-NAT 017 Study Team
Jul 11, 2006·Drugs·Vicki Oldfield, Greg L Plosker