Predictive factors related to the efficacy of golimumab in patients with rheumatoid arthritis

Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
Katsuaki KanbeAkiko Yabuki

Abstract

In order to investigate the predictive factors related to clinical efficacy and radiographic progression at 24 weeks by looking at the serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 including baseline characteristics in patients with rheumatoid arthritis (RA) treated with golimumab, serum concentrations of TNF-α and IL-6 were analyzed every 4 weeks up to 24 weeks in 47 patients treated with golimumab. Baseline levels of the Disease Activity Score 28 C-reactive protein (DAS28-CRP) and Simplified Disease Activity Index (SDAI) scores were also assessed. Radiographic progression using the van der Heijde-modified Sharp (vdH-S) score was assessed in 29 patients. Multiple regression analyses related to the DAS28-CRP score and delta total sharp score at 24 weeks was undertaken using the baseline characteristics of patients and serum concentrations of matrix metallo-proteinase (MMP)-3, TNF-α, and IL-6. The DAS28-CRP score and SDAI decreased significantly at 4 weeks up to 24 weeks compared with baseline. Serum levels of TNF-α were not changed significantly up to 24 weeks compared with baseline, but those of IL-6 decreased significantly at 4 weeks up to 8 weeks. Multiple regression analyses showed that disease durati...Continue Reading

References

Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN
Nov 29, 2011·Annals of the Rheumatic Diseases·Yoshiya TanakaUNKNOWN GO-FORTH Study Group
Jun 7, 2013·Annals of the Rheumatic Diseases·Bernard CombeUNKNOWN GO-MORE Investigators

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BETA
enzyme-linked immunosorbent assay

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Flex
Stat

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