Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.

PLoS Computational Biology
Kyriaki Sidiropoulou, Panayiota Poirazi

Abstract

Proper functioning of working memory involves the expression of stimulus-selective persistent activity in pyramidal neurons of the prefrontal cortex (PFC), which refers to neural activity that persists for seconds beyond the end of the stimulus. The mechanisms which PFC pyramidal neurons use to discriminate between preferred vs. neutral inputs at the cellular level are largely unknown. Moreover, the presence of pyramidal cell subtypes with different firing patterns, such as regular spiking and intrinsic bursting, raises the question as to what their distinct role might be in persistent firing in the PFC. Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. We identify synaptic location within the basal dendrites as a feature of stimulus selectivity. Specifically, persistent activity-inducing stimuli consist of activated synapses that ar...Continue Reading

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Citations

Dec 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bardia F Behabadi, Bartlett W Mel
Jun 5, 2013·The European Journal of Neuroscience·Reinoud Maex, Volker Steuber
Oct 4, 2014·Frontiers in Cellular Neuroscience·Maria PsarrouPanayiota Poirazi
Jan 13, 2015·Progress in Neurobiology·George KastellakisPanayiota Poirazi
Jul 14, 2017·Journal of Neurophysiology·Athanasia PapoutsiPanayiota Poirazi
May 27, 2020·PLoS Computational Biology·Christopher B CurrinJoseph V Raimondo
Sep 9, 2015·Journal of Neural Engineering·Bryan HowellWarren M Grill
May 13, 2020·Nature Reviews. Neuroscience·Panayiota Poirazi, Athanasia Papoutsi

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Software Mentioned

Perceptron
IgorPro
gNMDA
NEURON
Matlab

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