Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

Nature Biotechnology
Morgan G I LangilleCurtis Huttenhower

Abstract

Profiling phylogenetic marker genes, such as the 16S rRNA gene, is a key tool for studies of microbial communities but does not provide direct evidence of a community's functional capabilities. Here we describe PICRUSt (phylogenetic investigation of communities by reconstruction of unobserved states), a computational approach to predict the functional composition of a metagenome using marker gene data and a database of reference genomes. PICRUSt uses an extended ancestral-state reconstruction algorithm to predict which gene families are present and then combines gene families to estimate the composite metagenome. Using 16S information, PICRUSt recaptures key findings from the Human Microbiome Project and accurately predicts the abundance of gene families in host-associated and environmental communities, with quantifiable uncertainty. Our results demonstrate that phylogeny and function are sufficiently linked that this 'predictive metagenomic' approach should provide useful insights into the thousands of uncultivated microbial communities for which only marker gene surveys are currently available.

References

Oct 24, 1997·Science·R L TatusovD J Lipman
Jan 23, 1999·Nature Genetics·B SnelM A Huynen
Nov 18, 2003·Annual Review of Genetics·Yan BoucherW Ford Doolittle
Jan 22, 2004·Bioinformatics·Emmanuel ParadisKorbinian Strimmer
Feb 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Konstantinos T Konstantinidis, James M Tiedje
Jul 12, 2005·Molecular Biology and Evolution·Manuel ZúñigaFernando González-Candelas
Jun 27, 2006·Ecology Letters·Jennifer E SmithForest L Rohwer
Jul 6, 2006·Applied and Environmental Microbiology·Todd DeSantisGary L Andersen
Jun 21, 2007·PLoS Biology·Jian XuJeffrey I Gordon
Oct 16, 2007·Current Opinion in Microbiology·Alice C McHardy, Isidore Rigoutsos
Feb 29, 2008·PLoS Biology·Nancy Knowlton, Jeremy B C Jackson
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
Feb 5, 2010·Bioinformatics·Donovan H Parks, Robert G Beiko
Mar 4, 2010·Nucleic Acids Research·Jesse R R ZaneveldRob Knight
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
May 6, 2010·Genome Biology·Justin KuczynskiRob Knight
May 12, 2010·Genome Research·Samuel ChaffronChristian von Mering
Aug 17, 2010·Bioinformatics·Robert C Edgar
Oct 5, 2010·PLoS Genetics·G SuenCameron R Currie
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Douglas B RasherMark E Hay
Nov 15, 2011·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Nov 18, 2011·Proceedings. Biological Sciences·Katie L BarottForest L Rohwer
Dec 6, 2011·Nucleic Acids Research·Scott Federhen
Dec 24, 2011·Nucleic Acids Research·Victor M MarkowitzNikos C Kyrpides
Mar 14, 2012·Nature Reviews. Genetics·Ilseung Cho, Martin J Blaser
May 4, 2012·Science Translational Medicine·Pawel GajerJacques Ravel
Jun 9, 2012·Nature Biotechnology·Rob KnightJack A Gilbert
Jun 16, 2012·Nature·Human Microbiome Project Consortium
Jun 22, 2012·PLoS Computational Biology·Sahar AbubuckerCurtis Huttenhower
Jul 4, 2012·Molecular Biology and Evolution·R Eric Collins, Paul G Higgs
Jul 27, 2012·The ISME Journal·J Kirk HarrisNorman R Pace
Sep 28, 2012·Genome Biology·Xochitl C MorganCurtis Huttenhower
Nov 8, 2012·PLoS Computational Biology·Steven W KembelJessica L Green
Dec 14, 2012·The ISME Journal·Adam C MartinyGordon Pusch
Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Noah FiererJ Gregory Caporaso

Citations

Mar 13, 2014·PloS One·Emily R DavenportYoav Gilad
Jun 19, 2014·MBio·Anna M SeekatzVincent B Young
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jun 24, 2014·Biotechnology for Biofuels·Diego Javier JiménezJan Dirk van Elsas
Jul 22, 2014·Applied Microbiology and Biotechnology·Jinbo XiongDemin Zhang
Aug 28, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Annalouise O'ConnorBrian J Bennett
Oct 23, 2014·PeerJ·Catherine A PfisterSean M Gibbons
Aug 19, 2014·Immunology Letters·Hu HuangDan Knights
Sep 16, 2014·Trends in Immunology·Gerard E Kaiko, Thaddeus S Stappenbeck
Nov 25, 2015·Cell Systems·Ebrahim AfshinnekooChristopher E Mason
Feb 2, 2016·Nature Medicine·M Gloria Dominguez-BelloJose C Clemente
Sep 27, 2016·Applied & Translational Genomics·Jaeyun SungNicholas Chia
Oct 24, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Avilés-JiménezJ Torres
Feb 21, 2016·BMC Bioinformatics·Minji KimOlgica Milenkovic
Feb 10, 2016·Clinics in Chest Medicine·Yvonne J Huang, John J LiPuma
Feb 5, 2016·Alcoholism, Clinical and Experimental Research·Robin M VoigtAli Keshavarzian
Jan 6, 2016·Nature Reviews. Endocrinology·Mikael Knip, Heli Siljander
Jan 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jeremiah J FaithJeffrey I Gordon
Jan 19, 2016·Frontiers in Microbiology·Pelin YilmazFrank O Glöckner
Feb 3, 2016·Frontiers in Veterinary Science·Anne L BallouMatthew D Koci
Jan 24, 2016·Journal of Crohn's & Colitis·Mireia Valles-ColomerJeroen Raes
Dec 30, 2015·Plant Physiology and Biochemistry : PPB·Youry PiiTanja Mimmo
Oct 2, 2015·Science Translational Medicine·Marie-Claire ArrietaBrett B Finlay
Feb 9, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Manoj J Mammen, Sanjay Sethi
Mar 19, 2014·Gastroenterology·Luke K UrsellRob Knight
Feb 4, 2014·Gastroenterology·Xochitl C Morgan, Curtis Huttenhower
Jan 23, 2016·Applied Microbiology and Biotechnology·Qing HeLiang Xiao
Nov 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jérôme BoursierAnna Mae Diehl
Dec 24, 2014·Cell Host & Microbe·Rachel N CarmodyPeter J Turnbaugh
Jan 9, 2016·Scientific Reports·Diyan LiJessica Satkoski Trask
Jan 7, 2016·Frontiers in Genetics·Alejandra Escobar-ZepedaAlejandro Sanchez-Flores
Nov 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·William B Whitman
Oct 20, 2015·Psychoneuroendocrinology·Aadil BharwaniPaul Forsythe
Mar 4, 2015·Cell Host & Microbe·Koji YasudaXochitl C Morgan
Mar 5, 2016·The ISME Journal·Mathieu AlmeidaS Dusko Ehrlich
Dec 23, 2015·Microbiome·Yuanyuan ChengKatherine Belov
Dec 21, 2014·Gut·Jonna JalankaWillem M de Vos
Dec 5, 2015·Frontiers in Microbiology·Charles J NewboldNeil R McEwan
Dec 1, 2015·Nature Communications·Cameron MyhrvoldPamela A Silver
Mar 10, 2015·Computational and Structural Biotechnology Journal·Florence Abram
Nov 28, 2015·Scientific Reports·Laetitia G E WilkinsClaus Wedekind
Oct 18, 2015·Journal of Microbiological Methods·Erica M ProsdocimiElena Crotti
Nov 25, 2014·Cell·Julia K GoodrichRuth E Ley
Oct 21, 2015·Frontiers in Microbiology·Ember M Morrissey, Rima B Franklin
Sep 29, 2015·Molecular Ecology·Linda L BlackallMadeleine J H van Oppen
Feb 2, 2016·The Journal of Investigative Dermatology·Jacquelyn S MeiselElizabeth A Grice
Mar 15, 2016·Nutrition & Metabolism·N MarungruangEden Tareke
Jan 15, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Valeria D'Argenio, Francesco Salvatore
Oct 1, 2015·Trends in Microbiology·U G Mueller, J L Sachs
Jun 18, 2015·Briefings in Bioinformatics·Wynand AlkemaSacha A F T van Hijum
Mar 21, 2016·Journal of Microbiological Methods·Antony T VincentSteve J Charette
Mar 17, 2016·Gut Microbes·Renee GreerNatalia Shulzhenko
Mar 18, 2016·Nucleic Acids Research·Yanming ZhangFangqing Zhao
Nov 25, 2014·Arthritis & Rheumatology·Mary-Ellen CostelloMatthew A Brown
Nov 1, 2016·Cellular and Molecular Gastroenterology and Hepatology·Hiroko Nagao-KitamotoNobuhiko Kamada
Aug 1, 2015·Molecular Nutrition & Food Research·Juana I MoseleMaría-José Motilva
Sep 2, 2015·ILAR Journal·Andreas HiergeistAndré Gessner
Jul 30, 2015·The Journal of Allergy and Clinical Immunology·Yvonne J HuangHomer A Boushey
Jul 22, 2015·Environmental Science and Pollution Research International·Cécile MilitonPatricia Bonin
Jun 4, 2016·Annals of Epidemiology·Matthew C B Tsilimigras, Anthony A Fodor
Apr 7, 2016·Trends in Microbiology·Li-Nan HuangWen-Sheng Shu
Oct 7, 2015·Microbiome·Jie Ning, Robert G Beiko
Jun 3, 2014·Biochimica Et Biophysica Acta·Maria C CenitAlexandra Zhernakova
Mar 31, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajPatrick M Gillevet
Sep 28, 2015·BMC Research Notes·Se-Ran JunAndrey A Gorin
Apr 18, 2015·The ISME Journal·Tracy D AinsworthWilliam Leggat
Sep 16, 2015·The ISME Journal·Marta Goberna, Miguel Verdú
Feb 13, 2015·Briefings in Bioinformatics·Marie Lisandra Zepeda MendozaM Thomas P Gilbert
Apr 14, 2016·Environmental Science and Pollution Research International·Lingwen WangLizhong Zhu
Oct 23, 2014·MicrobiologyOpen·Esther JiménezJuan M Rodríguez
Jul 7, 2015·Alimentary Pharmacology & Therapeutics·Emmanuel MontassierDan Knights
Jul 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ali KeshavarzianKathleen M Shannon
May 7, 2016·Bioinformatics·Alexander Eng, Elhanan Borenstein
Oct 6, 2015·Cell Systems·Y William YuBonnie Berger
May 10, 2015·Bioinformatics·Kathrin P AßhauerPeter Meinicke
Jul 25, 2015·Science·Mohamed S Donia, Michael A Fischbach
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jakub KreisingerSarah E Perkins
May 6, 2016·Frontiers in Microbiology·Kelvin WongMarirosa Molina
Aug 6, 2013·FEMS Microbiology Reviews·Eva BoonRobert G Beiko
Jun 10, 2015·Journal of Microbiological Methods·Glade DlottStephanie A Yarwood
May 31, 2015·American Journal of Epidemiology·Betsy Foxman, Emily T Martin
Jun 21, 2014·Immunity·Pieter C DorresteinRob Knight
Apr 23, 2015·Antonie van Leeuwenhoek·Lucas Dantas LopesRodrigo Mendes
Jan 15, 2015·The Journal of Infectious Diseases·James M HortonMartin J Blaser
Jun 7, 2014·Beneficial Microbes·G D A HermesHauke Smidt
Apr 19, 2016·Alimentary Pharmacology & Therapeutics·J R AllegrettiJ R Korzenik
May 13, 2015·Nature Reviews. Nephrology·Jonathan S BrombergEmmanuel F Mongodin
Apr 29, 2015·Nature Reviews. Microbiology·Eric A FranzosaCurtis Huttenhower
May 8, 2015·Science Translational Medicine·Benjamin D ShoganJohn C Alverdy
May 6, 2016·Frontiers in Microbiology·Juan JovelGane K-S Wong
Mar 27, 2015·Applied Microbiology and Biotechnology·Feng Ju, Tong Zhang
Apr 23, 2016·Genome Medicine·Marc Jan BonderAlexandra Zhernakova
Jan 13, 2015·Annual Review of Immunology·Silvia Caballero, Eric Pamer
Mar 1, 2015·FEMS Microbiology Reviews·Thulani P MakhalanyaneDon A Cowan
May 28, 2014·Journal of Insect Physiology·Mathieu PerniceFleur Ponton
Jan 9, 2015·The Journal of Allergy and Clinical Immunology·Christina E Westin-FLAME Microbiome Interest Group
Jan 9, 2015·The Journal of Allergy and Clinical Immunology·Yvonne J Huang, Homer A Boushey
Jan 21, 2015·Antonie van Leeuwenhoek·Miriane Acosta SaraivaLuiz Fernando Würdig Roesch
Mar 15, 2015·Gastroenterología y hepatología·Jose F Garcia-MazcorroJosé L Tamayo
Jul 2, 2014·Frontiers in Plant Science·Thomas J Sharpton
Apr 27, 2016·Journal of Basic Microbiology·Peris Mumbi MunyakaJean-Eric Ghia
Jan 8, 2015·Advances in Wound Care·Brendan P Hodkinson, Elizabeth A Grice
Nov 16, 2014·Applied and Environmental Microbiology·Mariana E KirstGary P Wang
Apr 27, 2016·Current Opinion in Biotechnology·Dmitrij Turaev, Thomas Rattei
Apr 29, 2016·Genome Medicine·Emmanuel MontassierDan Knights
Dec 4, 2015·PloS One·Laura MillaresAndrés Moya
Apr 28, 2016·The Journal of Allergy and Clinical Immunology·Jonathan P LaneAndrew R Gennery
May 7, 2016·The British Journal of Nutrition·M CandelaP Brigidi
May 3, 2016·International Journal of Molecular Sciences·Silvia ArboleyaMiguel Gueimonde
May 21, 2015·PloS One·Jan S SuchodolskiStanley L Marks
Jun 24, 2015·PloS One·Hélène MorlonBrendan J M Bohannan
May 14, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Helen TremlettUS Network of Pediatric MS Centers
Jun 1, 2016·Frontiers in Microbiology·Joshua C McCannJuan J Loor
May 11, 2016·Environmental Science & Technology·Chun-Yu LaiHe-Ping Zhao
May 18, 2016·Scientific Reports·A Braundmeier-FlemingDavid J Klumpp
Apr 30, 2016·FEMS Microbiology Ecology·Jose F Garcia-MazcorroGiuliana Noratto
Jun 4, 2016·BMC Medicine·Gili Zilberman-SchapiraEran Elinav
Jul 5, 2016·Frontiers in Microbiology·Silvia TurroniM Candela
Jun 14, 2016·The Journal of Allergy and Clinical Immunology·S BunyavanichJose C Clemente
Aug 31, 2016·Nature Microbiology·Sara Vieira-SilvaJeroen Raes
Nov 20, 2014·PloS One·Jeffrey D GalleyLisa M Christian
Sep 13, 2016·Molecular Metabolism·Stavros BashiardesEran Elinav
Apr 3, 2016·Journal of Applied Microbiology·R P RevettaN J Ashbolt
Jul 14, 2016·Genomics Data·Sujay PaulMarcel Gutiérrez-Correa
Jun 28, 2016·Bone Marrow Transplantation·D ZamaA Pession
Jul 9, 2016·Nature Medicine·Sabrina TamburiniJose C Clemente
Jul 10, 2016·Current Allergy and Asthma Reports·Juliana DurackSusan V Lynch
Aug 3, 2013·Genome Medicine·Daniela BörnigenCurtis Huttenhower
Aug 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Naga S BetrapallyJasmohan S Bajaj
Jul 20, 2016·Trends in Microbiology·Jason W ArnoldM Andrea Azcarate-Peril
Sep 13, 2016·Molecular Metabolism·Siegfried UssarC Ronald Kahn
Jul 31, 2016·Microbiome·Francesco StratiCarlotta De Filippo
Aug 12, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Cecilia NoeckerElhanan Borenstein
Aug 16, 2016·Microbiome·Jessica J EichmillerPeter W Sorensen
Sep 1, 2016·Frontiers in Microbiology·Madhavi L KakumanuMark A Williams
Sep 2, 2016·Frontiers in Microbiology·Huan LiXiangzhen Li
Oct 27, 2016·Nature Microbiology·Alexandra E LivanosMartin J Blaser
Sep 10, 2016·Frontiers in Microbiology·Lucas D LopesFernando D Andreote
Aug 31, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jonathan B ClaytonDan Knights
Aug 27, 2016·Environmental Science & Technology·Chun-Yu LaiHe-Ping Zhao
Sep 8, 2016·Environmental Science & Technology·Erica M HartmannJessica L Green
Aug 3, 2016·Annual Review of Microbiology·Joerg Graf
Sep 10, 2016·The ISME Journal·Ruben PropsNico Boon
Oct 21, 2015·Trends in Molecular Medicine·Stefano Fiorucci, Eleonora Distrutti
Sep 13, 2016·Research in Microbiology·Filipa Godoy-VitorinoPedro Miguel Santos
Sep 17, 2016·Science·Stilianos LoucaMichael Doebeli
Apr 14, 2016·Molecular Nutrition & Food Research·Caroline ThumNicole C Roy
Oct 7, 2016·Frontiers in Microbiology·Kirsten M Ellegaard, Philipp Engel
Jun 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dae Joong KangJasmohan S Bajaj
Sep 27, 2016·PloS One·Andrea R OttesenJames Robert White
Aug 11, 2016·Molecular Ecology·Laetitia G E WilkinsClaus Wedekind
Sep 2, 2016·Environmental Microbiology·Mónica RoucoSonya T Dyhrman
Jul 8, 2016·Microbes and Environments·Satoshi HiraokaWataru Iwasaki
Oct 4, 2016·Nature Microbiology·Yoshiki Vázquez-BaezaRob Knight
Sep 18, 2015·GigaScience·Peter E Larsen, Yang Dai
Aug 5, 2016·Pediatric Research·Judit BassolsJosé-Manuel Fernández-Real
Oct 7, 2016·Extremophiles : Life Under Extreme Conditions·Rafael José Marques PeixotoRegina Maria Cavalcanti Pilotto Domingues
Oct 6, 2016·Nature Genetics·Williams TurpinKenneth Croitoru
Oct 30, 2016·Frontiers in Microbiology·Himanshu KumarSeppo Salminen
Sep 26, 2016·The Science of the Total Environment·Chan Lan ChunMichael J Sadowsky
Oct 27, 2016·Chemical Research in Toxicology·Robert G NicholsAndrew D Patterson
Oct 21, 2016·FEMS Microbiology Ecology·Mincheol KimYoo Kyung Lee
Nov 11, 2016·AMB Express·Amrita Kumari PandaNachimuthu Senthil Kumar
Aug 5, 2016·Environmental Microbiology·Karen A CameronCarsten S Jacobsen
Jul 26, 2014·Bioinformatics·Donovan H ParksRobert G Beiko
Sep 18, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin LelouvierJacques Amar
Oct 25, 2016·Environmental Microbiology Reports·Josh D Neufeld
Nov 14, 2016·The Journal of Allergy and Clinical Immunology·Juliana DurackNational Heart, Lung and Blood Institute's “AsthmaNet”
Apr 22, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·Christopher J StewartD J West
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Patricio S La RosaPhillip I Tarr
Jul 23, 2016·PLoS Neglected Tropical Diseases·Irina V SaltykovaPaul J Brindley
Jan 5, 2017·Gut Microbes·Michael J SadowskyAlexander Khoruts
Jan 16, 2016·Molecular Nutrition & Food Research·Nadeem O KaakoushMargaret J Morris
Jan 10, 2017·Scientific Reports·Xue XiaoJames Y W Lau
Aug 12, 2014·Systematic Biology·Frederick A Matsen
Dec 20, 2015·PLoS Computational Biology·James KaminskiCurtis Huttenhower
Dec 2, 2016·Environmental Microbiology·Brett Wagner MackenzieKristi Biswas
Jul 23, 2016·American Journal of Respiratory and Critical Care Medicine·Meera K ShenoySusan V Lynch
Nov 7, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cyriac Abby PhilipsShiv K Sarin
Feb 15, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Erin M Hill-BurnsHaydeh Payami
Feb 9, 2017·International Journal of Molecular Sciences·Elisa BorghiAglaia Vignoli
Jan 27, 2017·Annual Review of Food Science and Technology·Aaron M WalshPaul D Cotter
Jun 22, 2016·Scientific Reports·Alfred A ChanDelphine J Lee
May 27, 2016·Scientific Reports·Vishwadeep AhluwaliaJasmohan S Bajaj
Apr 30, 2016·Scientific Reports·Chan Hyuk ParkChang Soo Eun
Jan 31, 2017·The Science of the Total Environment·Stefano CampanaroViviana Corich
Nov 3, 2016·Scientific Reports·J L WoodAshley E Franks
Jun 24, 2016·PloS One·Felipe Pinheiro de OliveiraIda Vanessa Doederlein Schwartz
Jan 19, 2016·Scientific Reports·Stinus LindgreenPaul P Gardner
Feb 22, 2017·Annals of Neurology·Helen TremlettEmmanuelle Waubant
Mar 31, 2017·PloS One·Kristin L DolanJennifer B H Martiny
Apr 6, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lama NazzalJerome Lowenstein
Mar 21, 2017·International Journal of Cancer. Journal International Du Cancer·Guoqin YuAlisa M Goldstein
Apr 9, 2017·Journal of Veterinary Internal Medicine·D E GomezJ S Weese
Feb 14, 2015·Molecular Plant-microbe Interactions : MPMI·Julia K CopelandDavid S Guttman
Nov 25, 2015·Scientific Reports·Christopher J StewartNicholas D Embleton
Mar 15, 2016·Scientific Reports·Angela B JavurekCheryl S Rosenfeld
Feb 24, 2015·Scientific Reports·Jiro NakayamaYuan-Kun Lee
Aug 22, 2014·Scientific Reports·Rosine E TiodjioAkira Ueda
Apr 28, 2017·PLoS Computational Biology·Charles K FisherAleksandra M Walczak
May 17, 2017·The ISME Journal·Laura BaldoWalter Salzburger
Apr 9, 2017·The Journal of Biological Chemistry·Kristina B MartinezEugene B Chang
Dec 23, 2016·International Journal of Systematic and Evolutionary Microbiology·Seok-Hwan YoonJongsik Chun
Jun 7, 2017·Gut Microbes·Burkhardt FlemerJean-François Brugère
Jun 10, 2017·Antonie van Leeuwenhoek·Murali GopalKamlesh Jangid
Jul 30, 2014·The ISME Journal·Peter E LarsenJack A Gilbert
Mar 7, 2017·Environmental Science. Processes & Impacts·Hassan WaseemSyed A Hashsham
Jan 18, 2017·Microbiome·Kyle HartmanKlaus Schlaeppi
Feb 12, 2017·Nature Communications·Maren ZieglerChristian R Voolstra
Feb 16, 2017·Clinical & Translational Immunology·Lieke Wj van den ElsenElizabeth E Forbes-Blom
Mar 23, 2017·Medicine·Marc Noguera-JulianVincent C Marconi
May 24, 2016·Environmental Science. Processes & Impacts·Blake HansonJoanne E Sordillo
Jun 20, 2017·Environmental Science & Technology·Qing-Lin ChenLi Cui
Jun 5, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jesse LyonsKen S Lau
Jul 12, 2017·Microbial Biotechnology·Javad GharechahiGhasem Hosseini Salekdeh
Aug 30, 2016·Reproduction, Fertility, and Development·Angela B JavurekCheryl S Rosenfeld
Jul 22, 2017·The ISME Journal·Wyatt H HartmanSusannah G Tringe
Mar 16, 2018·Gut Microbes·Christopher John KielyClaire Louise O'Brien
Jan 11, 2018·Allergy·M FazlollahiS Bunyavanich
Jan 28, 2018·Applied and Environmental Microbiology·Qiang LiQinya Ge
Feb 11, 2018·Applied and Environmental Microbiology·Jolinda PollockMick Watson
Mar 4, 2014·Inflammatory Bowel Diseases·Michael DavenportP'ng Loke
Jan 12, 2016·Inflammatory Bowel Diseases·Timna NaftaliUri Gophna
Jun 1, 2016·Inflammatory Bowel Diseases·James J AshtonDavid W Cleary
Jul 29, 2015·Inflammatory Bowel Diseases·Rita-Marie T McFaddenPawel R Kiela
Feb 1, 2018·International Journal of Molecular Sciences·Valeria D'Argenio
Jan 20, 2018·International Journal of Molecular Sciences·Ariadna S Sánchez-LópezSofie Thijs
Feb 8, 2018·Molecular Ecology·Tiffany PrestValerie J McKenzie
Mar 3, 2018·Bioengineering·Firouz AbbasianSebastian Magierowski
Feb 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang ChiKun Lu
Mar 25, 2018·MicrobiologyOpen·Wirulda PootakhamSithichoke Tangphatsornruang
Mar 9, 2018·Applied Microbiology and Biotechnology·Dongwei HouJianguo He
Jan 20, 2018·Annual Review of Food Science and Technology·Francesca De FilippisDanilo Ercolini
Mar 27, 2018·PloS One·M Alexandra García-AmadoM Gloria Dominguez-Bello
Feb 28, 2018·Microbiome·Stilianos LoucaLaura Wegener Parfrey
Feb 24, 2018·The Journal of Experimental Medicine·Stefanie SchmidtStefan Rose-John
Apr 4, 2018·Genes·Junhui GuoLuoping Zhang
Apr 5, 2018·Journal of Animal Science·Henry A PazSamodha C Fernando
Oct 31, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriTREAT Consortium
Jan 3, 2018·Molecular Ecology·Teresita M Porter, Mehrdad Hajibabaei
Mar 30, 2018·World Journal of Microbiology & Biotechnology·Katiúscia Kelli Montanari-CoelhoAlexandre Lima Nepomuceno
Apr 10, 2018·Journal of Dental Research·M PereraN W Johnson
Apr 11, 2018·American Journal of Primatology·Xuecong LiuZhigang Jiang
Aug 24, 2017·Asian-Australasian Journal of Animal Sciences·Minseok KimZhongtang Yu
Nov 7, 2015·BMC Biology·Emma Saxon
Oct 27, 2017·Microbiome·Kaisa KoskinenChristine Moissl-Eichinger
Nov 1, 2017·Scientific Reports·Hasinika K A H GamageIan T Paulsen
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Adam R BurnsBrendan J M Bohannan
Mar 10, 2018·Physiological Genomics·M R PanasevichR S Rector
Apr 11, 2018·Nature Reviews. Clinical Oncology·Bertrand RoutyGuido Kroemer
May 25, 2016·Molecular BioSystems·M F AddisP Moroni
Nov 18, 2017·Scientific Reports·Maria-Soledad BenitezR Michael Lehman
Sep 14, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·R AraosErika M C D'Agata
Feb 6, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Miranda M SungJason R B Dyck
Apr 21, 2017·Asian-Australasian Journal of Animal Sciences·Ju Kyoung OhDae-Kyung Kang
Jun 12, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·M R PanasevichR S Rector
May 20, 2018·World Journal of Microbiology & Biotechnology·Ngoc Tuan TranShan-Gong Wu
Nov 23, 2017·Scientific Reports·Natalia Castaño-RodríguezNadeem O Kaakoush
May 21, 2016·Evolutionary Bioinformatics Online·Vanessa Aguiar-PulidoGiri Narasimhan
Mar 8, 2018·Arthritis & Rheumatology·Isabel Lopez-OlivaPurnima S Kumar
Jul 30, 2014·Nature Communications·Daniel I BolnickRichard Svanbäck