Predictive markers of AIDS: a follow-up of lymphocyte subsets and HIV serology in a cohort of patients with lymphadenopathy

Scandinavian Journal of Infectious Diseases
B BöttigerG Biberfeld

Abstract

From 1982 to 1985, 89 HIV-1 seropositive men with persistent generalized lymphadenopathy (PGL) were enrolled into a prospective longitudinal study. In February 1988, after a mean observation time of 45 months, 23 patients had progressed to AIDS with opportunistic infection (AIDS/OI), 4 had developed Kaposi's sarcoma, 47 had developed HIV-related symptoms, 14 still had PGL as only symptom, and 1 was lost to follow-up. Patients with CD4 lymphocytes less than or equal to 0.40 x 10(9)/l as well as patients with HIV antigenaemia and those lacking antibodies to p24 all had a significantly higher risk of developing AIDS/OI within 30 months of observation than other patients. HIV antigen was present in 70% and antibodies to p24 were lacking in 61% of the patients at the time of AIDS/OI diagnosis. All but one (96%) of the AIDS/OI patients had CD4 numbers less than or equal to 0.20 x 10(9)/l at the same time. The estimated median time to AIDS/OI in patients with HIV antigenaemia was 21 months and in patients lacking p24 antibodies 27 months. In patients with CD4 numbers less than or equal to 0.20 and 0.40 x 10(9) cells/l the estimated median time to AIDS/OI was 14 months and longer than 30 months, respectively.

References

Nov 1, 1988·European Journal of Haematology·B BöttigerG Biberfeld
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·J GerstoftE Dickmeiss
Oct 1, 1988·The Journal of Infectious Diseases·B IsakssonP Putkonen

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Citations

Feb 1, 1993·Journal of Medical Virology·E LuchtA Heimdahl
Sep 16, 1998·AIDS Research and Human Retroviruses·S J PopperP J Kanki
Jan 1, 1991·Scandinavian Journal of Infectious Diseases·L Morfeldt-MånsonL V von Stedingk
Jan 1, 1994·Clinical Microbiology Reviews·C M Tsoukas, N F Bernard

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