Jan 1, 1987

Predictive models for deposition of inhaled diesel exhaust particles in humans and laboratory species

Research Report
C P Yu, G B Xu

Abstract

Mathematical and computer models of the respiratory tracts of human beings and of laboratory animals (rats, hamsters, guinea pigs) were used to estimate the deposition patterns of inhaled diesel exhaust particles from automobile emissions. The accuracy of these models was tested by comparing the calculated depositions in laboratory animals with actual laboratory data. Our goal was to be able to predict the relation between exposure to diesel exhaust particles and the deposition of these particles in the lungs of humans of various ages. Diesel exhaust particles are aggregates with a mass median aerodynamic diameter of approximately 0.2 micron. Their actual size depends on the conditions under which they are generated. Using an appropriate particle model, we derived mathematical expressions that describe the effects of diffusion, sedimentation, impaction, and interception on the deposition of these particles. Because of their small size, we found that most diesel exhaust particles deposited through diffusion, and that the role of the other mechanisms was minor. Anatomical models of the human lung from birth to adulthood, as well as models of the lungs of laboratory species were formulated mathematically using available morphometr...Continue Reading

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Mentioned in this Paper

Engine Exhaust
Respiratory Tract Structure
Lung
Normal Respiratory Function
Impacted Tooth
Cavia
Alveolar
Weighing Patient
Hamsters
Breath

About this Paper

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