Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates

Infectious Diseases and Therapy
Chris StockmannAdam Frymoyer

Abstract

The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Utilization of population pharmacokinetic models and Bayesian methods offers the potential for developing individualized therapeutic approaches. To meet this need, a neonatal vancomycin population pharmacokinetic model was recently published. The current study sought to externally evaluate the predictive performance and generalizability of this model. A retrospective chart review of neonates who received vancomycin and had ≥1 peak and ≥1 trough concentrations at five Intermountain Healthcare neonatal intensive care units from 2006 to 2013 was performed and served as the external validation cohort. The published population pharmacokinetic model was implemented in NONMEM 7.2 with the structural and variance parameter values set equal to the estimates reported previously. The model was then used to predict the first peak and trough concentration for each neonate in the validation cohort and the model prediction error and absolute prediction error were calculated. Normalized predic...Continue Reading

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Citations

Sep 29, 2015·Journal of Clinical Pharmacology·Jiraganya Jj BhongsatiernCatherine M T Sherwin
Jun 27, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jeffrey J CiesArun Chopra
Nov 4, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jacopo Colombo, Ilenia Scaffidi
Jan 3, 2018·Journal of the Pediatric Infectious Diseases Society·Adam FrymoyerRon J Keizer
Aug 1, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brady S MoffettAyse A Arikan
Mar 6, 2019·Antimicrobial Agents and Chemotherapy·Frank KloproggeJoseph F Standing
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Aug 2, 2017·Future Microbiology·Nazario D Rivera-ChaparroRachel G Greenberg
Aug 26, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jennifer T Pham
Jan 12, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Sadie B StoneCarl H Coghill
Dec 16, 2020·Antimicrobial Agents and Chemotherapy·Hiroshi SasanoKazuhiko Hanada
Mar 7, 2021·The Journal of Antimicrobial Chemotherapy·Sarah C J JorgensenBruce R Dalton
Mar 13, 2021·Frontiers in Pediatrics·Alan AbdullaMatthijs de Hoog
Sep 8, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Hidehiko MaruyamaTetsuya Isayama
Apr 26, 2020·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S VeluzatJ Sarlangue

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Software Mentioned

NONMEM
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