Predictive Performance of Exposome Score for Schizophrenia in the General Population.

Schizophrenia Bulletin
Lotta-Katrin PriesSinan Guloksuz

Abstract

Previously, we established an estimated exposome score for schizophrenia (ES-SCZ) as a cumulative measure of environmental liability for schizophrenia to use in gene-environment interaction studies and for risk stratification in population cohorts. Hereby, we examined the discriminative function of ES-SCZ for identifying individuals diagnosed with schizophrenia spectrum disorder in the general population by measuring the area under the receiver operating characteristic curve (AUC). Furthermore, we compared this ES-SCZ method to an environmental sum score (Esum-SCZ) and an aggregate environmental score weighted by the meta-analytical estimates (Emet-SCZ). We also estimated ORs and Nagelkerke's R2 for ES-SCZ in association with psychiatric diagnoses and other medical outcomes. ES-SCZ showed a good discriminative function (AUC = 0.84) and statistically significantly performed better than both Esum-SCZ (AUC = 0.80) and Emet-SCZ (AUC = 0.80). At optimal cut point, ES-SCZ showed similar performance in ruling out (LR- = 0.20) and ruling in (LR+ = 3.86) schizophrenia. ES-SCZ at optimal cut point showed also a progressively greater magnitude of association with increasing psychosis risk strata. Among all clinical outcomes, ES-SCZ was as...Continue Reading

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Citations

Mar 20, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Gamze ErzinSinan Guloksuz
Jun 15, 2021·Frontiers in Psychiatry·Lotta-Katrin PriesSinan Guloksuz
Sep 11, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Celso ArangoPaolo Fusar-Poli
Nov 26, 2021·The British Journal of Clinical Psychology·Emiliana ToniniMelissa J Green

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