Predictive Place-Cell Sequences for Goal-Finding Emerge from Goal Memory and the Cognitive Map: A Computational Model

Frontiers in Computational Neuroscience
Lorenz GönnerFred H Hamker

Abstract

Hippocampal place-cell sequences observed during awake immobility often represent previous experience, suggesting a role in memory processes. However, recent reports of goals being overrepresented in sequential activity suggest a role in short-term planning, although a detailed understanding of the origins of hippocampal sequential activity and of its functional role is still lacking. In particular, it is unknown which mechanism could support efficient planning by generating place-cell sequences biased toward known goal locations, in an adaptive and constructive fashion. To address these questions, we propose a model of spatial learning and sequence generation as interdependent processes, integrating cortical contextual coding, synaptic plasticity and neuromodulatory mechanisms into a map-based approach. Following goal learning, sequential activity emerges from continuous attractor network dynamics biased by goal memory inputs. We apply Bayesian decoding on the resulting spike trains, allowing a direct comparison with experimental data. Simulations show that this model (1) explains the generation of never-experienced sequence trajectories in familiar environments, without requiring virtual self-motion signals, (2) accounts for ...Continue Reading

References

Jul 1, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Marr
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·R Ben-YishaiH Sompolinsky
Apr 1, 1993·Hippocampus·M W Jung, B L McNaughton
Jun 1, 1996·The Journal of General Physiology·R U MullerJ Pach
Jan 1, 1996·Memory & Cognition·M J Kahana
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·T SeidenbecherD Balschun
Jan 1, 1997·Journal of Computational Neuroscience·W Gerstner, L F Abbott
Mar 21, 1998·Neural Computation·A D Redish, D S Touretzky
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pengcheng Song, Xiao-Jing Wang
Jul 15, 2005·Journal of Neurophysiology·Romain Brette, Wulfram Gerstner
Jun 28, 2006·The European Journal of Neuroscience·John Apergis-SchouteDenis Paré
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Pascal Pfister, Wulfram Gerstner
Feb 17, 2007·Science·Jill K LeutgebEdvard I Moser
Sep 11, 2007·Nature Neuroscience·Kamran Diba, György Buzsáki
Aug 28, 2009·Neuron·Thomas J DavidsonMatthew A Wilson
Sep 15, 2009·Nature Neuroscience·Gabrielle GirardeauMichaël B Zugaro
Dec 10, 2009·PLoS Computational Biology·Eleni VasilakiWulfram Gerstner
Dec 17, 2009·Frontiers in Neuroscience·Dan F M Goodman, Romain Brette
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·John J Hopfield
Jan 26, 2010·Nature Neuroscience·Claudia ClopathWulfram Gerstner
Mar 13, 2010·Neuron·Anoopum S GuptaA David Redish
Jul 10, 2010·PLoS Computational Biology·Daniel BushMichael O'Shea
Jul 20, 2010·Nature Neuroscience·David DupretJozsef Csicsvari
Aug 21, 2010·Frontiers in Computational Neuroscience·Julien Vitay, Fred H Hamker
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Trevor J HamiltonWilliam F Colmers
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Loren M Devito, Howard Eichenbaum
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vladimir ItskovGyörgy Buzsáki

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Citations

Apr 3, 2020·The European Journal of Neuroscience·Javier Baladron, Fred H Hamker

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