PMID: 16613336Apr 15, 2006Paper

Predictive probability of serum prostate-specific antigen for prostate cancer: an approach using Bayes rule

American Journal of Clinical Pathology
Robin T Vollmer

Abstract

This article introduces the use of Bayes probability rule to calculate age and serum prostate-specific antigen (PSA)-specific positive predictive values (PPVs) for prostate cancer. The PPV is the conditional probability of having prostate cancer, given a value of PSA and a particular age group. The formulation uses values of sensitivity obtained from previously reported studies of more than 2,700 men with prostate cancer, and it uses values of specificity obtained from previously reported studies of more than 99,000 men without prostate cancer. The formulation also introduces the use of a population-based and age-specific probability of prostate cancer, and for this it relies on the National Cancer Institute-sponsored Surveillance, Epidemiology and End Results data. The Bayes PPV suggests that in younger men, cut points defining an elevated PSA level should be raised rather than lowered. The Bayes formulation also provides estimates of the PPV for narrow intervals of PSA, and these tabulated results may provide useful guidelines for the implications of serum PSA levels at specific age groups.

References

Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Jan 1, 1984·Medical Decision Making : an International Journal of the Society for Medical Decision Making·R GrayR A Greenes
May 11, 1996·Lancet·R SawyerG W Moore
Aug 1, 1996·The New England Journal of Medicine·T O MorganJ W Moul
Nov 25, 1996·Archives of Internal Medicine·S J JacobsenM M Lieber
Apr 14, 1999·Journal of Clinical Epidemiology·P A Godley, M J Schell
Mar 22, 2002·The Journal of Urology·M C WangT M Chu
Jul 4, 2002·Journal of the National Cancer Institute·Siu-Long Yao, Grace Lu-Yao
Jul 4, 2002·Journal of the National Cancer Institute·Ruth EtzioniEric J Feuer
Mar 1, 1995·The Canadian Journal of Urology·J E Oesterling
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Jul 25, 2003·The New England Journal of Medicine·Rinaa S PungliaKaren M Kuntz
Jul 25, 2003·The New England Journal of Medicine·Fritz H Schröder, Ries Kranse
Apr 20, 2004·Critical Reviews in Oncology/hematology·Hans-Peter SchmidLadislav Prikler
May 28, 2004·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Oct 12, 2004·Biostatistics·Ori Davidov, Marvin Zelen

❮ Previous
Next ❯

Citations

Apr 15, 2006·American Journal of Clinical Pathology·Kristin R SwansonLawrence D True
Jun 7, 2006·American Journal of Clinical Pathology·M Natalie Grunkemeier, Robin T Vollmer
Dec 6, 2006·American Journal of Clinical Pathology·Robin T Vollmer
Oct 10, 2006·Pediatric Clinics of North America·Ulrich BroeckelSubra Kugathasan
Jan 17, 2007·Prostate Cancer and Prostatic Diseases·K T BogenE A Holly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Clinical Pathology
M Natalie Grunkemeier, Robin T Vollmer
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Heidi A van VugtMonique J Roobol
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bob DjavanMichael Marberger
© 2022 Meta ULC. All rights reserved