Predictive, protective, orphan autoantibodies: the example of anti-phospholipid antibodies

Autoimmunity Reviews
Pier Luigi Meroni, Y Shoenfeld

Abstract

Anti-phospholipid antibodies (aPL) are one of the most recent examples of autoantibodies that can appear even long time before any clinical manifestation can be associated with them. There is a general agreement that they may represent a strong risk factor for recurrent thrombosis and/or fetal losses. Anti-phospholipid antibodies represent a necessary but not sufficient factor (first hit) for thrombosis, and require additional triggering factors (second hit) to disclose the thrombogenic activity. Several factors may affect the predictive value of aPL, including titre, immunoglobulin isotype, fine antigenic specificity and affinity binding activity. Their careful evaluation is suggested in order to characterize the true predictive value of aPL.

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Citations

Dec 4, 2008·Clinical Reviews in Allergy & Immunology·Silvia BucciarelliRicard Cervera
Oct 21, 2009·Clinical Reviews in Allergy & Immunology·Ricard Cervera, Juan Balasch
Jun 7, 2012·Clinical Reviews in Allergy & Immunology·M Ángeles Martínez-ZamoraJuan Balasch
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Dec 26, 2012·Autoimmunity Reviews·Dimitrios P BogdanosYehuda Shoenfeld
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Jun 20, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Dolores PérezAntonio Serrano
Jun 15, 2021·Frontiers in Immunology·Marvin J FritzlerMichael Mahler

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Related Concepts

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.