Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancer.

Breast Cancer Research : BCR
Piiha-Lotta JerevallOlle Stål

Abstract

The HOXB13:IL17BR index has been identified to predict clinical outcome in the setting of adjuvant tamoxifen monotherapy of breast cancer. Further studies have shown that HOXB13 in particular can indicate benefit of prolonged tamoxifen treatment. Patients with high-expressing tumors did not benefit from prolonged treatment, suggesting that HOXB13 might be involved in tamoxifen resistance. No studies have been made regarding the HOXB13 protein levels in breast cancer. The aim of our study was to investigate whether tamoxifen benefit can be correlated to different levels of HOXB13 protein expression. We used immunohistochemistry to analyze protein levels of HOXB13 in tumor samples from 912 postmenopausal node-negative breast cancer patients randomized to adjuvant tamoxifen therapy or no endocrine treatment. Tamoxifen-treated patients with estrogen receptor-positive tumors expressing none or low levels of HOXB13 had a clear benefit from tamoxifen in terms of longer distant recurrence-free survival (DRFS) (hazard ratio = 0.38, 95% confidence interval = 0.23 to 0.60, P = 0.000048). However, for patients with a high or intermediate HOXB13 tumor expression, tamoxifen did not prolong the DRFS compared with the untreated patients (hazar...Continue Reading

References

Jun 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C Vermeulen-MeinersJ H Thijssen
May 20, 2000·Journal of Mammary Gland Biology and Neoplasia·R G LapidusN E Davidson
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Jan 3, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M CantileC Cillo
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew P GoetzFergus J Couch
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xiao-Jun MaMark G Erlander
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurice P H M JansenEls M J J Berns
Apr 25, 2007·Breast Cancer Research and Treatment·Piiha-Lotta JerevallOlle Stål
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zuncai WangDennis C Sgroi
Mar 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Mathis GrossmannGeorge Jerums
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Jun MaDennis Sgroi
May 24, 2008·Carcinogenesis·Benjamin A T RodriguezTim H-M Huang

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Citations

Aug 3, 2012·The New England Journal of Medicine·Shaheen AlaneeKenneth Offit
Nov 22, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Valeria BarresiGiovanni Tuccari
Sep 17, 2013·Veterinary and Comparative Oncology·P DeinnocentesR Curtis Bird
Dec 13, 2016·Metallomics : Integrated Biometal Science·S BlockhuysP Wittung-Stafshede
Jul 25, 2012·Nature Reviews. Clinical Oncology·Karin BeelenSabine C Linn
May 30, 2019·Cancers·Gerardo BottiMonica Cantile
Feb 1, 2017·The Journal of Pathology. Clinical Research·Janna PaulssonArne Östman
Jun 18, 2020·Scientific Reports·Jingjing LiuAntoinette Hollestelle
Nov 7, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Subrata MannaMarina K Holz
Jan 8, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Virpi H LaitinenJohanna Schleutker

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Methods Mentioned

BETA
PCR

Software Mentioned

Statistica

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