Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Takaaki TokitoTomoaki Hoshino

Abstract

Expression of programmed cell death-ligand 1 (PD-L1) is known to be a mechanism whereby cancer can escape immune surveillance, but little is known about factors predictive of efficacy in patients with locally advanced non-small cell lung cancer (NSCLC). We investigated the predictive relevance of PD-L1 expression and CD8+ tumour-infiltrating lymphocytes (TILs) density in patients with locally advanced NSCLC receiving concurrent chemoradiotherapy (CCRT). We retrospectively reviewed 74 consecutive patients with stage III NSCLC who had received CCRT. PD-L1 expression and CD8+ TIL density were evaluated by immunohistochemical analysis. Univariate and multivariate analyses demonstrated that CD8+ TIL density was an independent and significant predictive factor for progression-free survival (PFS) and OS, whereas PD-L1 expression was not correlated with PFS and OS. Sub-analysis revealed that the PD-L1+/CD8 low group had the shortest PFS (8.6 months, p = 0.02) and OS (13.9 months, p = 0.11), and that the PD-L1-/CD8 high group had the longest prognosis (median PFS and OS were not reached) by Kaplan-Meier curves of the four sub-groups. Among stage III NSCLC patients who received CCRT, there was a trend for poor survival in those who expre...Continue Reading

References

Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KonishiMasaharu Nishimura
Dec 3, 2005·Nature Reviews. Immunology·Michael H KershawPhillip K Darcy
Sep 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A William Blackstock, Ramaswamy Govindan
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khalid I Al-ShibliLill-Tove Busund
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie-Caroline Dieu-NosjeanJacques Cadranel
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerSuzanne L Topalian
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Aug 8, 2012·Clinical Lung Cancer·Jennifer M BolandMarie Christine Aubry
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R Brahmer
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mario Sznol, Lieping Chen
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laszlo RadvanyiPatrick Hwu
Oct 15, 2013·The Journal of Pathology·Jérôme GalonFranck Pagès
Aug 8, 2014·The Cancer Journal·Miguel F Sanmamed, Lieping Chen
Feb 5, 2015·Journal of the National Cancer Institute·Kurt A SchalperDavid L Rimm
Feb 11, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Moon-Young KimDoo Hyun Chung
Feb 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tom DonnemLill-Tove Busund
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Aug 28, 2015·PloS One·Lars Henning SchmidtWolfgang Hartmann

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Citations

Nov 7, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hironori UrugaMari Mino-Kenudson
Jun 2, 2016·PloS One·Toshiaki HaraguchiKoichi Ohshima
May 10, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Xiaomei GongCaicun Zhou
Nov 2, 2017·Nature Reviews. Urology·Richard C WalshawAnanya Choudhury
Jun 14, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·T OnoH Umeno
Oct 12, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhigang WeiQingyu Li
Apr 3, 2019·International Journal of Molecular Sciences·Carlo CapalboArmando Bartolazzi
Oct 14, 2017·Journal of Gynecologic Oncology·Jun ZhuXiaohua Wu
Nov 16, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Junghoon ShinJong-Seok Lee
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Mark BustorosIrene M Ghobrial
May 31, 2019·Archives of Pharmacal Research·Su-Myeong Park, Je-In Youn
Aug 5, 2020·JCO Global Oncology·Abdul Rahman JaziehWalid E Khalbuss
Jul 10, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Rudolf M HuberAmanda Tufman
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emeka K EnwereCorinne M Doll
Jan 27, 2019·Frontiers of Medicine·Min ZhangQijun Qian
Oct 20, 2018·Journal of the Egyptian National Cancer Institute·Dina M El-GuindyMohamed Abo El-Nasr
Jul 3, 2017·Pathology Oncology Research : POR·Olga Stasikowska-KanickaMarian Danilewicz
Oct 16, 2018·British Journal of Cancer·Jean-David FumetFrançois Ghiringhelli

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