Predictive reward signal of dopamine neurons

Journal of Neurophysiology
W Schultz

Abstract

The effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse suggest that midbrain dopamine systems are involved in processing reward information and learning approach behavior. Most dopamine neurons show phasic activations after primary liquid and food rewards and conditioned, reward-predicting visual and auditory stimuli. They show biphasic, activation-depression responses after stimuli that resemble reward-predicting stimuli or are novel or particularly salient. However, only few phasic activations follow aversive stimuli. Thus dopamine neurons label environmental stimuli with appetitive value, predict and detect rewards and signal alerting and motivating events. By failing to discriminate between different rewards, dopamine neurons appear to emit an alerting message about the surprising presence or absence of rewards. All responses to rewards and reward-predicting stimuli depend on event predictability. Dopamine neurons are activated by rewarding events that are better than predicted, remain uninfluenced by events that are as good as predicted, and are depressed by events that are worse than predicted. By signaling rewards according to a prediction error, dopamine responses have the formal char...Continue Reading

References

Aug 15, 1975·The Journal of Comparative Neurology·T HattoriP L McGeer
Jun 10, 1977·Brain Research·P F Gilbert, W T Thach
Oct 1, 1977·Journal of Comparative and Physiological Psychology·D E Edmonds, C R Gallistel
Jul 1, 1978·Annals of Neurology·K A Flowers, A C Downing
Dec 1, 1978·The Journal of Comparative Neurology·A H Lohman, I van Woerden-Verkley
Mar 12, 1976·Brain Research·A G PhillipsH C Fibiger
Nov 1, 1992·Trends in Neurosciences·M Kawato, H Gomi
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J SurmeierS T Kitai
Oct 1, 1992·Journal of Neurophysiology·J H Maunsell, J R Gibson
Jan 1, 1992·Annual Review of Psychology·N M White, P M Milner
Jan 1, 1992·Journal of Neurophysiology·T LjungbergW Schultz
Feb 1, 1992·Brain : a Journal of Neurology·M A PastorJ A Obeso
Jun 1, 1992·Journal of Neurophysiology·M MatsumuraO Hikosaka
Jul 15, 1990·The Journal of Comparative Neurology·L D Selemon, P S Goldman-Rakic
Feb 22, 1991·Science·T Sawaguchi, P S Goldman-Rakic

❮ Previous
Next ❯

Citations

Feb 17, 2000·Annals of the New York Academy of Sciences·L R LucasB S McEwen
Feb 7, 2001·Annual Review of Psychology·E T Rolls
Jan 12, 2001·Physiological Reviews·J T WilliamsO Manzoni
Feb 13, 2001·Journal of Neurophysiology·M J GdowskiJ C Houk
Mar 20, 2001·Neural Computation·R E Suri, W Schultz
Aug 10, 2001·Neuroreport·D L RobinsonR M Wightman
Apr 20, 2002·Addiction·Daniel H Lende, E O Smith
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daphna Joel, Julia Doljansky
Feb 27, 2003·The European Journal of Neuroscience·Mufida El-GhundiSusan R George
Nov 27, 2002·Evaluation & the Health Professions·Raúl De La Fuente-Fernández, A Jon Stoessl
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Carlos A PaladiniRichard D Palmiter
Jul 16, 2003·The European Journal of Neuroscience·Manuel RodríguezErnesto Pereda
Oct 7, 2003·Annual Review of Neuroscience·Paul W Glimcher
Jul 31, 2003·Journal of Neurochemistry·Peter M BungayJoseph B Justice
Sep 23, 2003·Clinical Chemistry·Donita L RobinsonR Mark Wightman
Nov 25, 2003·The Spanish Journal of Psychology·Robert A Rescorla
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy A Wise
Feb 27, 2004·The European Journal of Neuroscience·Peter J Brasted, Steven P Wise
Mar 9, 2004·Nature Neuroscience·Dominic J BarracloughDaeyeol Lee
Jul 31, 2004·Journal of Integrative Neuroscience·Hiroshi Tsujino
Nov 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Garret D StuberR Mark Wightman
Nov 19, 2004·Journal of Neurophysiology·Samuel D Gale, David J Perkel
Jan 7, 2005·Journal of Neurophysiology·Satoshi Tsujimoto, Toshiyuki Sawaguchi
Jun 9, 2005·Journal of Learning Disabilities·Sabrina E B Schuck, Francis M Crinella
Apr 16, 2005·Nature Reviews. Neuroscience·Leo P SugrueWilliam T Newsome
Jul 8, 2005·Psychopharmacology·Christopher J MacDonald, Warren H Meck
Dec 29, 2005·Neuroscience and Behavioral Physiology·K B Shapovalova
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John Blakey
Feb 28, 2006·Nature Neuroscience·Ziv M Williams, Emad N Eskandar
Oct 13, 2006·Psychopharmacology·Yael NivPeter Dayan
Apr 15, 2006·Network : Computation in Neural Systems·Maia K Janowitz, Mark C W van Rossum
Jul 15, 2006·Journal of Cognitive Neuroscience·Elizabeth TricomiJulie A Fiez
Jul 28, 2006·Journal of Neurophysiology·Samuel D Gale, David J Perkel
May 23, 2006·Experimental Brain Research·Daeyeol Lee, Marc H Schieber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
W Schultz
Annual Review of Neuroscience
W Schultz, Anthony Dickinson
© 2022 Meta ULC. All rights reserved