PMID: 24353716Dec 20, 2013Paper

Predictive role of Glutathione S-transferases (GSTs) on the prognosis of osteosarcoma patients treated with chemotherapy

Pakistan Journal of Medical Sciences
Jia-Wen TengBo Xu

Abstract

We conducted a comprehensive study to investigate the role of GSTM1, GSTTI and GSTP1 genetic variation involved in transport pathways in response to chemotherapy and clinical outcome of osteosarcoma. A total of 146 patients were included in our study between January 2008 and December 2009. All the patients were followed up to death or January 2012. Genotyping of GSTM1, GSTT1 and GSTP1 was conducted in a 384-well plate format on the Sequenom MassARRAY platform. Sixty seven patients (45.9%) died during the follow-up period. The median age of patients was 14.2 years and ranged from 9.3 to 38.7 years. The median follow-up time was 29.6 months (range 5 to 60 months). Individuals with GSTP1 G/G genotype tended to live shorter than A/A genotype, and we found a significantly higher risk of death from osteosarcoma (adjusted HR=2.73, 95% CI=1.05-7.45). Individuals with the GSTP GG genotype were more likely to have a poor response to chemotherapy, with an OR of 2.73 (95%CI, 1.07-7.81). However, we did not find association of polymorphisms in GSTM1 and GSTT1 with response to chemotherapy and prognosis of osteosarcoma. Our study provides information for prediction of treatment outcome in clinical oncology. Due to the limited number of sampl...Continue Reading

Citations

Jun 23, 2015·Expert Opinion on Drug Metabolism & Toxicology·Claudia Maria Hattinger, Massimo Serra
Jun 1, 2016·The Pharmacogenomics Journal·M Serra, C M Hattinger
Jun 30, 2016·Drug Discovery Today·Hanneke I VosDunja Maroeska W M Te Loo
Mar 2, 2019·Expert Opinion on Drug Metabolism & Toxicology·Claudia Maria HattingerMassimo Serra
Jul 8, 2020·International Journal of Molecular Sciences·Claudia Maria HattingerMassimo Serra
Feb 7, 2021·BMC Musculoskeletal Disorders·Wei LiuGuangrong Ji

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