Predictive sensitivity of human cancer cells in vivo using semipermeable polysulfone fibers

Pharmacology
M Y ChuP Calabresi

Abstract

An in vivo experimental model was developed to predict efficiently and accurately chemosensitivity of human tumors. Human cancer cells either from cultured cell lines or from patients' tumors were injected directly into semipermeable polysulfone fibers subsequently implanted into immunocompetent rats. Results suggest utility of this novel model system for predicting tumor sensitivity to a wide range of anticancer agents and for potentially guiding the treatment of cancer patients in the clinical setting.

Citations

Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie SuggittMichael C Bibby

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