Predictive significance of magnetic resonance imaging at 4 months of adjusted age in infants after a perinatal neurologic insult

Biology of the Neonate
V MilletN Girard

Abstract

The aim of this prospective study was to evaluate the predictive significance of magnetic resonance imaging (MRI) performed at 4 months of corrected age in 60 neonates after a perinatal neurologic insult. Follow-up ranged from 2 to 5 years of chronological age. MRI examination was normal in 10; isolated external hydrocephalus was found in 15 infants. Twenty-three of these infants developed normally. Focal or multifocal lesions were shown in 6 infants, of whom 2 developed normally. Diffuse brain involvement was present in 29 cases as atrophy (n = 18), leukomalacia (n = 5), basal ganglia lesions (n = 3), and delayed myelination (n = 3). All but 4 infants showed neurologic impairment. MRI performed at 4 months of adjusted age is of prognostic significance in neonates who suffer a moderate or mild neurologic insult.

Citations

Mar 20, 2002·Current Neurology and Neuroscience Reports·M Scher
Apr 30, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·L G CornetteM I Levene
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·B E Porter, G Tennekoon

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