Predictive validity of NEDA in the 16- and 21-year follow-up from the pivotal trial of interferon beta-1b

Multiple Sclerosis : Clinical and Laboratory Research
Douglas S GoodinIFNB Multiple Sclerosis Study Group and the 16- and 21-Year LTF Investigators

Abstract

Long-term follow-up from the randomized trial of interferon beta-1b (IFNB-1b) permitted the assessment of different definitions of no evidence of disease activity (NEDA) for predicting long-term outcome in multiple sclerosis (MS). To examine the predictive validity of different NEDA definitions. Predictive validity for negative disability outcomes (NDOs) at 16 years and survival at 21 years post-randomization were assessed. NEDA in the first 2 years was defined as follows: clinical NEDA: no relapses or Expanded Disability Status Scale (EDSS) progression from baseline to Year 2; NEDA-3a: no relapses, no confirmed ⩾1-point EDSS progression, and no new T2-active lesions; NEDA-3b: no relapses, no EDSS progression, and no increase in T2 burden of disease (T2-BOD); and NEDA-4: no relapses, no EDSS progression, and no increase in T2-BOD or atrophy. NDOs were defined as death, need for wheelchair, EDSS ⩾6, or progressive MS. A total of 245 and 371 patients were evaluated at 16 and 21 years, respectively. Clinical NEDA predicted NDOs ( p = 0.0029), as did baseline EDSS ( p < 0.0001), baseline T2-BOD ( p < 0.0001), and change in T2-BOD ( p = 0.0033). IFNB-1b treatment ( p = 0.0251), relapse rate in the 2 years before study start ( p = 0....Continue Reading

References

Jan 1, 1995·Duodecim; lääketieteellinen aikakauskirja·M PaneliusJ Ruutiainen
Jun 21, 2006·Annals of Neurology·Richard A RudickElizabeth Fisher
Oct 8, 2009·Clinical Therapeutics·George C EbersUNKNOWN Investigators of the 16-Year Long-Term Follow-Up Study
Jun 22, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·G C EbersUNKNOWN Investigators of the 16-year Long-Term Follow-Up Study
Dec 6, 2011·PloS One·Douglas S GoodinUNKNOWN 16-Year Long-Term Follow-up Study Investigators
Dec 24, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Douglas S GoodinUNKNOWN 16-Year Long Term Follow-up Study Investigators
Mar 26, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Veronica PopescuUNKNOWN MAGNIMS Study Group
Jul 3, 2013·Multiple Sclerosis : Clinical and Laboratory Research·H KearneyD T Chard
Jul 22, 2015·Multiple Sclerosis and Related Disorders·Gavin GiovannoniMonica Marta
Sep 13, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Marcello MocciaVincenzo Brescia Morra
Oct 4, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Alfredo DamascenoFernando Cendes
Nov 21, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Ludwig KapposDavorka Tomic
Jul 28, 2016·Annals of Neurology·UNKNOWN University of California, San Francisco MS-EPIC Team:Stephen L Hauser
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Anthony L TraboulseeDavid Kb Li

❮ Previous
Next ❯

Citations

Apr 2, 2019·Developmental Medicine and Child Neurology·Sophie DuignanYael Hacohen
Nov 16, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Thor Ameri ChalmerMelinda Magyari
Jan 25, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Luca ProsperiniClaudio Gasperini
Apr 21, 2020·Expert Review of Neurotherapeutics·Eleonora TavazziNiels Bergsland
Jul 14, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mark S FreedmanUNKNOWN Canadian MS Working Group
Mar 2, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lorena LoreficeEleonora Cocco
Jan 25, 2021·QJM : Monthly Journal of the Association of Physicians·L DumitrescuR Tanasescu
Feb 11, 2021·Life·Ruggiero SecciaFrancesca Grassi
Dec 21, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Marcus W KochGary Cutter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Multiple Sclerosis : Clinical and Laboratory Research
Mark S Freedman
Neurology. Neuroimmunology and Neuroinflammation
Natalie E ParksEoin P Flanagan
© 2022 Meta ULC. All rights reserved