Predictive Value of 99mTc-MAA SPECT for 90Y-Labeled Resin Microsphere Distribution in Radioembolization of Primary and Secondary Hepatic Tumors

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Harun IlhanAlexander R Haug

Abstract

This study analyzed the predictive value of (99m)Tc-labeled macroaggregated albumin ((99m)Tc-MAA) SPECT for (90)Y-labeled resin microsphere therapy (radioembolization) by comparing uptake on pretherapeutic (99m)Tc-MAA SPECT with uptake on posttherapeutic (90)Y-bremsstrahlung SPECT. We included 502 patients (55% male; mean age ± SD, 62 ± 11 y) who underwent radioembolization between 2005 and 2013 because of primary or secondary liver malignancies (colorectal cancer [n = 195, 38.8%], neuroendocrine tumors [n = 77, 15.3%], breast cancer [n = 68, 13.5%], hepatocellular carcinoma [n = 59, 11.8%], cholangiocellular carcinoma [n = 40, 8.0%], or urologic tumors [n = 14, 2.8%]). Manually drawn regions of interest around tumors and adjacent healthy liver tissue for up to 3 lesions per patient on (99m)Tc-MAA and (90)Y-bremsstrahlung scans were used to quantify mean counts per pixel and evaluate the mean tumor-to-background ratio (TBR). Data were given as mean ± SD. Additionally, uptake in lesions on (99m)Tc-MAA and (90)Y-bremsstrahlung scans was graded visually as homogeneously higher than (grade 1), heterogeneously higher than (grade 2), equal to (grade 3), or lower than (grade 4) uptake in normal liver tissue. The Mann-Whitney U test an...Continue Reading

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Citations

Oct 13, 2016·The British Journal of Radiology·Stephan WalrandFrançois Jamar
Jan 11, 2019·Journal of Applied Clinical Medical Physics·Senait Aknaw DebebeAnthony J McGoron
Nov 6, 2018·EJNMMI Physics·Remco BastiaannetHugo W A M de Jong
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May 4, 2017·AJR. American Journal of Roentgenology·Hossein Jadvar
Dec 22, 2020·Nihon Hoshasen Gijutsu Gakkai zasshi·Kohei HanaokaHiroyuki Tsushima
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Nov 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander Robert Haug, Harun Ilhan
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Mar 17, 2020·Neuroendocrinology·Rahul KanabarAngela Lamarca

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