PMID: 9527126Apr 4, 1998Paper

Predictive value of an adherence test for acute otitis media

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J DaninoM Barak

Abstract

The predictive value of an in vitro adherence test of the bacterium Streptococcus pneumoniae for the development of recurrent otitis media was calculated 5 years after the initial test. Nasopharyngeal cells from 56 children suffering from acute otitis media (AOM) and from healthy children were tested for adherence of a standard pneumococcal type (capsular serotype 6). The average adherence of the bacteria to epithelial cells from the group suffering from AOM was greater than the average adherence in the control group (p < 0.005), both when adherence was counted microscopically and radioactively. Subjects were followed up periodically over a 5-year period. Four out of 5 healthy children who had high mean adherence values experienced AOM during the 5 years, and 1 child classified as AOM-prone was found to be healthy. Based on the retrospective data, the positive predictive value of this test was 98.2%, and the negative predictive value was 90.7%.

References

Feb 1, 1992·The Journal of Laryngology and Otology·L E Stenfors, S Räisänen
Jun 1, 1992·The Journal of Infectious Diseases·L E Stenfors, S Räisänen
Jul 1, 1991·International Journal of Pediatric Otorhinolaryngology·L E Stenfors, S Räisänen
Jan 1, 1989·Respiration; International Review of Thoracic Diseases·B Andersson, C Svanborg-Edén
Jul 1, 1988·The Pediatric Infectious Disease Journal·B AnderssonC S Edén

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