Predictive value of C-reactive protein and left ventricular diastolic filling pattern after a non-ST elevation myocardial infarction

The American Journal of the Medical Sciences
Achilles ZacharoulisApostolos Zacharoulis

Abstract

Recent studies have shown that the odds ratio for high-sensitivity C-reactive protein (CRP) in predicting a coronary events in healthy subjects is 1.4, a value substantially less than previously reported. It is unclear whether this extends to acute coronary syndrome patients or if CRP would predict long-term events in this population. We evaluated the predictive value of CRP in patients with non-ST segment elevation myocardial infarction (NSTEMI) as their first manifestation of coronary artery disease and compared it with that of left ventricle diastolic function. Serum CRP concentration measurement and left ventricle diastolic function evaluation were performed in 51 consecutive patients with NSTEMI 48 hours, 3 months, and 6 months after infarction. Patients were followed for 1 year and events comprising the endpoints of death, new myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting were reported. Thirty of 51 patients developed the endpoints. Mean CRP concentration in patients who developed any endpoint and those who did not was similar at 48 hours, 3 months, and 6 months. A strong correlation between the presence of impaired relaxation 6 months after the infarction and development o...Continue Reading

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Citations

Jul 19, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rakesh K MishraNelson B Schiller
Apr 9, 2008·La Revue de médecine interne·F RoubilleF Leclercq
Jun 26, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rakesh K MishraRichard B Devereux

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