Predictive value of circulating cystatin C level in patients with acute coronary syndrome: a meta-analysis.

Scandinavian Journal of Clinical and Laboratory Investigation
Song JinPengying Gu

Abstract

Circulating cystatin C level has been identified as a predictor of adverse outcomes in patients with coronary artery disease (CAD). This meta-analysis aimed to investigate the value of circulating cystatin C level for predicting adverse outcomes in patients with acute coronary syndrome (ACS). We comprehensively searched articles indexed in Pubmed and Embase databases from their inceptions to 30 November 2019. All available observational studies that investigated the association between circulating cystatin C level and major adverse cardiovascular events [MACE] (including death, heart failure, re-infarction, target vascular revascularization, angina and stroke) or all-cause mortality in patients with ACS were included. The prognostic value was expressed by pooling the multivariable-adjusted hazard risk (HR) with 95% confidence interval (CI) for the highest versus the lowest category of cystatin C level. Eleven eligible studies (12 articles) with 4600 ACS patients were identified. Meta-analysis indicated that the highest versus lowest category of cystatin C level was associated with higher risk of MACE (HR 2.28; 95% CI 1.92-2.71) and all-cause mortality (HR 2.89; 95% CI 1.43-5.83) after adjustment for estimated glomerular filtrat...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Dec 18, 2004·Critical Reviews in Clinical Laboratory Sciences·Michele Mussap, Mario Plebani
Dec 21, 2004·Clinical Biochemistry·Guido FillerAnders Grubb
Aug 13, 2008·International Journal of Cardiology·Antonios P AntoniadisGeorge D Giannoglou
Apr 11, 2009·Clinical Chemistry·Fons WindhausenUNKNOWN Invasive versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS) Investigators
Jul 15, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Eiji IchimotoIssei Komuro
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
May 24, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zhongheng ZhangNi Jin
Feb 24, 2012·The American Journal of Cardiology·Doroteia SilvaFausto J Pinto
Jun 2, 2012·Heart & Lung : the Journal of Critical Care·Tong-Wen SunLe-Xin Wang
Jul 24, 2012·The American Journal of Cardiology·Sergio Manzano-FernándezFrancisco Marín
Apr 2, 2015·The New England Journal of Medicine·Gregory A RothChristopher J L Murray
Dec 10, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Alain DardashtiHenrik Bjursten
Feb 16, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Erik HerouHenrik Bjursten
Apr 2, 2019·BioMed Research International·Xiangbing MaoJun He
Aug 10, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hua ZhouNing Xu
May 28, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Anna ÅkessonAnders Grubb

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