PMID: 11920789Mar 29, 2002Paper

Predictive value of clinical evaluation in the follow-up of children with a brain tumor

Medical and Pediatric Oncology
Nanko de GraafSiebold S N de Graaf

Abstract

During follow-up of children with a brain tumor, traditionally surveillance-imaging studies are done in addition to clinical evaluations. The purpose of this study was to determine the role of clinical evaluations by a multidisciplinary team for the detection of recurrent tumor. We retrospectively assessed the predictive value of clinical evaluation, using subsequent neuroimaging as the gold standard. Ninety-eight children with a newly diagnosed primary brain tumor were included in the study. In these patients, 393 imaging studies were done, 75 because of clinical suspicion of recurrence, and 318 for routine surveillance only. In 28 of these 75 imaging studies on clinical indications, a radiologic diagnosis of recurrence was made. Only 9 out of 318 routine surveillance imaging studies resulted in an unexpected diagnosis of recurrence. Thus, the overall positive predictive value of clinical evaluation was 37%; the overall negative predictive value was 97%. The negative predictive values for specific brain tumors varied from 91% (optical glioma) to 99% (primitive neuroectodermal tumors). An accurate multidisciplinary clinical evaluation has a very high negative predictive value. Consequently, the added value of surveillance imagi...Continue Reading

References

Mar 31, 1994·The New England Journal of Medicine·C F TorresB J Lange
May 1, 1996·Journal of Neurosurgery·L N SuttonP Phillips
May 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D W ShawK L Lindsley

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Citations

Dec 8, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Michael VassilyadiEnrique Ventureyra
Dec 25, 2019·The Cochrane Database of Systematic Reviews·Gerard ThompsonMichael D Jenkinson
Aug 24, 2011·Pediatric Radiology·Sue C Kaste

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